atrial fibrillation, familial, 7
Findings
No curated finding names atrial fibrillation, familial, 7 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any familial atrial fibrillation in which the cause of the disease is a mutation in the KCNA5 gene.
Definition from the Mondo Disease Ontology (MONDO:0012828), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Middle age onset · Early young adult onset · Late young adult onset
HPO, annotations 2026-09-02
Features
7 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- PalpitationsHPOHP:0001962
- 29 of 31 reported patients
- Premature atrial contractionsHPOHP:0006699
- 16 of 20 reported patients
- Paroxysmal atrial fibrillationHPOHP:0004757
- 12 of 22 reported patients
- Prolonged PR intervalHPOHP:0012248
- 1 of 2 reported patients
- Prolonged QTc intervalHPOHP:0005184
- 1 of 2 reported patients
- Permanent atrial fibrillationHPOHP:0004754
- 9 of 19 reported patients
- Sinus bradycardiaHPO
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- KCNA5HGNC:6224
- Moderate · Ambry Genetics · Autosomal dominant · 2024
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- Limited · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2017
Where it sits
- A kind of
Other names
3 names
Resolves to: atrial fibrillation, familial, 7
- Also called
- atrial fibrillation, familial, type 7familial atrial fibrillation caused by mutation in KCNA5KCNA5 familial atrial fibrillation