Sulfonyldimethane has no detected effect on interleukin‑6 concentration

no difference foundModerate evidenceFinding

01 · The sentence it was drawn from

“There was also no significant difference in the amount of change in IL-1 beta, IL-6, and Hs-CRP between the MSM and placebo groups during any week of comparison (Supplementary Table S2).”

Quoted verbatim from Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.

This finding among the 81 findings on its endpoint

sulfonyldimethane

Interleukin-6 concentration

no difference found

Who: Healthy Japanese adults with mild knee pain (Kellgren-Lawrence grade 0 or 1); per-protocol set; change from baseline at each visit up to 12 weeks
Dose studied: 10 tablets per day, 200 mg MSM per tablet, vs lactose tablets

Moderate evidencePMID 37447322 · 2023

02 · The study

Study: RCT
Duration: 3 months

Evidence, by strength

strong
moderatethis finding
limited
very limited
insufficient

03 · The paper

Nutrients

Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.

2023PMID 37447322doi 10.3390/nu15132995

What else it reported2 findings · 1 compound · 2 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M71FZR54ME3040ZQ3CTTYFMT