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Catalyst

sulfonyldimethaneFinding

Sulfonyldimethane has no detected effect on C-reactive protein concentration

no difference foundModerate evidenceFinding

01 · The sentence it was drawn from

“There was also no significant difference in the amount of change in IL-1 beta, IL-6, and Hs-CRP between the MSM and placebo groups during any week of comparison (Supplementary Table S2).”
Quoted verbatim from Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.
This finding among the 114 findings on its endpoint

sulfonyldimethane

C-reactive protein concentration

no difference found

Who
Healthy Japanese adults with mild knee pain (Kellgren-Lawrence grade 0 or 1); per-protocol set; change from baseline at each visit up to 12 weeks
Dose studied
10 tablets per day, 200 mg MSM per tablet, vs lactose tablets

Moderate evidencePMID 37447322 · 2023

02 · The study

Study
RCT
Duration
3 months

Evidence, by strength

  • strong
  • moderatethis finding
  • limited
  • very limited
  • insufficient

03 · The paper

Nutrients
What else it reported2 findings · 1 compound · 2 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M71FZRKXFAAZN5K81GYQE3JA