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sodium nitriteFinding

Sodium nitrite increases plasma nitrite concentration

raisesVery limited evidenceFindingreplicated ×1

01 · The sentence it was drawn from

“Ten weeks of sodium nitrite (80 or 160 mg/day, capsules, TheraVasc; randomized, placebo control, double blind) increased plasma nitrite acutely (5- to 15-fold, P < 0.001 vs. placebo) and chronically (P < 0.10) and was well tolerated without symptomatic hypotension or clinically relevant elevations in blood methemoglobin.”

Quoted verbatim from Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults.

This finding among the 14 findings on its endpoint

sodium nitrite

Plasma nitrite concentration

raises

Who: middle-aged and older adults
Dose studied: 80 or 160 mg/day

Very limited evidencePMID 26607249 · 2016

02 · The study

Study: RCT
Duration: 2 months

Evidence, by strength

strong
moderate
limited
very limitedthis finding
insufficient

03 · The paper

Journal of applied physiology (Bethesda, Md.

Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults.

2016PMID 26607249doi 10.1152/japplphysiol.00879.2015

A later check left this paper out of the papers counted for sodium nitrite; the finding stays because it matches the quoted sentence.

What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M38PEQPJJEKHTYSV1REDT680