Papers/PMID:24740143
Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.
PloS one2014The record
9 findings · 1 compound · 9 endpoints · 9 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
9 findings
α-tocopherol — no detected effect on systolic blood pressure (setting unspecified)
Evidence strength: moderate.FindingNull result“Furthermore, vitamin E supplementation failed to significantly alter either systolic blood pressure (SBP) or diastolic blood pressure (DBP) compared with the control group.”
Quoted verbatim from Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- Adults with type 2 diabetes mellitus; randomised trials of vitamin E supplementation versus placebo or control
Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.2014PMID:2474014310.1371/journal.pone.0095008Permalink
α-tocopherol — no detected effect on LDL cholesterol
Evidence strength: moderate.FindingNull resultreplicated ×1“Vitamin E supplementation also appeared to have no statistically significant effect on lipid metabolism, including triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C), compared with placebo.”
Quoted verbatim from Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- Adults with type 2 diabetes mellitus; randomised trials of vitamin E supplementation versus placebo or control
Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.2014PMID:2474014310.1371/journal.pone.0095008Permalink
α-tocopherol — no detected effect on diastolic blood pressure (setting unspecified)
Evidence strength: moderate.FindingNull result“Furthermore, vitamin E supplementation failed to significantly alter either systolic blood pressure (SBP) or diastolic blood pressure (DBP) compared with the control group.”
Quoted verbatim from Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- Adults with type 2 diabetes mellitus; randomised trials of vitamin E supplementation versus placebo or control
Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.2014PMID:2474014310.1371/journal.pone.0095008Permalink
α-tocopherol — no detected effect on glycated haemoglobin (HbA1c)
Evidence strength: moderate.FindingNull result“There was no significant reduction in the percentage of HbA1c (−0.24, 95% CI: −0.49 to 0.02]; P = 0.07, Figure 2), with significant evidence of interstudy heterogeneity (I2 = 67%; P = 0.0005) in subjects with vitamin E supplements, so we reported the results from random-effects models.”
Quoted verbatim from Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Dose
- 200 to 1600 IU/d across trials
- Population
- Adults with type 2 diabetes mellitus; 12 randomised trials (608 subjects) of vitamin E supplementation versus placebo or control, doses 200 to 1600 IU/d, 6 to 27 weeks
Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.2014PMID:2474014310.1371/journal.pone.0095008Permalink
α-tocopherol — no detected effect on HOMA-IR
Evidence strength: moderate.FindingNull result“Vitamin E resulted in no significant decrease in HOMA-IR (−0.32, 95% CI:−0.65 to 0.01, P = 0.06) or postprandial glucose (−0.20, 95% CI: −1.07 to 0.67, P = 0.65) compared with controls.”
Quoted verbatim from Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- Adults with type 2 diabetes mellitus; three randomised trials of vitamin E supplementation versus placebo or control
Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.2014PMID:2474014310.1371/journal.pone.0095008Permalink
α-tocopherol — no detected effect on triglycerides
Evidence strength: moderate.FindingNull result“Vitamin E supplementation also appeared to have no statistically significant effect on lipid metabolism, including triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C), compared with placebo.”
Quoted verbatim from Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- Adults with type 2 diabetes mellitus; randomised trials of vitamin E supplementation versus placebo or control
Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.2014PMID:2474014310.1371/journal.pone.0095008Permalink
Show the remaining 3
α-tocopherol — no detected effect on HDL cholesterol
Evidence strength: moderate.FindingNull resultreplicated ×1“Vitamin E supplementation also appeared to have no statistically significant effect on lipid metabolism, including triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C), compared with placebo.”
Quoted verbatim from Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- Adults with type 2 diabetes mellitus; randomised trials of vitamin E supplementation versus placebo or control
Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.2014PMID:2474014310.1371/journal.pone.0095008Permalink
α-tocopherol — no detected effect on total cholesterol (TC)
Evidence strength: moderate.FindingNull resultreplicated ×1“Vitamin E supplementation also appeared to have no statistically significant effect on lipid metabolism, including triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C), compared with placebo.”
Quoted verbatim from Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- Adults with type 2 diabetes mellitus; randomised trials of vitamin E supplementation versus placebo or control
Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.2014PMID:2474014310.1371/journal.pone.0095008Permalink
α-tocopherol — no detected effect on fasting blood glucose
Evidence strength: moderate.FindingNull resultreplicated ×3“Meta-analyses suggested that vitamin E supplementation, compared with a placebo or control, resulted in no statistically significant improvement (0.12 mmol/l, 95% CI: −0.34 to 0.58 mmol/l, P = 0.60, Figure 3) in fasting glucose status.”
Quoted verbatim from Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Dose
- 200 to 1600 IU/d across trials
- Population
- Adults with type 2 diabetes mellitus; 12 randomised trials (587 participants) of vitamin E supplementation versus placebo or control
Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.2014PMID:2474014310.1371/journal.pone.0095008Permalink