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1,501–1,550 of 12,877 reactions from Human-GEM
dimethylallyl-PP[c] + farnesyl-PP[c] = PPi[c] + trans,trans,cis-geranyl-geranyl-pp[c]
Left to rightBalancedEC 2.5.1.10N-glycan metabolismHuman-GEM MAR01532
5alpha-cholesta-7,24-dien-3beta-ol[c] + H+[c] + NADPH[c] = lathosterol[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.72Cholesterol biosynthesis 2Human-GEM MAR01533
H+[e] + NH4+[c] = H+[c] + NH4+[e]
ReversibleBalancedTransportEC 2.7.4.6Transport reactionsHuman-GEM MAR01534
H+[c] + lanosterol[c] + NADPH[c] = 24,25-dihydrolanosterol[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.72Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01535
24,25-dihydrolanosterol[c] + H+[c] + NADPH[c] + O2[c] = 4,4-dimethyl-14alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.154Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01536
NH4+[c] = NH4+[n]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01537
4,4-dimethyl-14alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4,4-dimethyl-14alpha-formyl-5alpha-cholesta-8-en-3beta-ol[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.154Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01538
4,4-dimethyl-14alpha-formyl-5alpha-cholesta-8-en-3beta-ol[c] + NADPH[c] + O2[c] = 4,4-dimethyl-5alpha-cholesta-8,14-dien-3-beta-ol[c] + formate[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.154Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01539
4,4-dimethyl-5alpha-cholesta-8,14-dien-3-beta-ol[c] + H+[c] + NADPH[c] = 4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.70Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01540
NH4+[c] = NH4+[x]
ReversibleBalancedTransportEC 2.7.4.6Transport reactionsHuman-GEM MAR01541
ATP[c] + H+[c] + nicotinamide D-ribonucleotide[c] = NAD+[c] + PPi[c]
Left to rightBalancedEC 2.7.4.6Nicotinate and nicotinamide metabolismHuman-GEM MAR01542
4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01543
4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-formyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01544
4alpha-formyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01545
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + NADP+[c] = 4alpha-methyl-5alpha-cholesta-8-en-3-one[c] + CO2[c] + H+[c] + NADPH[c]
Left to rightBalancedEC 1.1.1.170Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01546
4alpha-methyl-5alpha-cholesta-8-en-3-one[c] + H+[c] + NADPH[c] = 4alpha-methyl-cholesta-8-enol[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.270Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01547
4alpha-methyl-cholesta-8-enol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01548
4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-formyl-5alpha-cholesta-8-en-3beta-ol[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01549
4alpha-formyl-5alpha-cholesta-8-en-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01550
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol[c] + NADP+[c] = 5alpha-cholesta-8-en-3-one[c] + CO2[c] + H+[c] + NADPH[c]
Left to rightBalancedEC 1.1.1.170Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01551
5alpha-cholesta-8-en-3-one[c] + H+[c] + NADPH[c] = cholestenol[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.270Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01552
cholestenol[c] = lathosterol[c]
Left to rightBalancedEC 5.3.3.5Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Human-GEM MAR01553
ATP[m] + H+[m] + nicotinate ribonucleotide[m] = deamido-NAD[m] + PPi[m]
Left to rightBalancedEC 2.7.7.18Nicotinate and nicotinamide metabolismHuman-GEM MAR01554
ATP[c] + H2O[c] + noradrenaline[c] = ADP[c] + H+[c] + noradrenaline[e] + Pi[c]
Left to rightBalancedTransportEC 2.7.7.18Transport reactionsHuman-GEM MAR01555
(15Z)-tetracosenoylcarnitine[m] + CoA[m] = (15Z)-tetracosenoyl-CoA[m] + L-carnitine[m]
ReversibleBalancedEC 2.1.1.28Fatty acid oxidationHuman-GEM MAR01556
H+[c] + lathosterol[c] + NADH[c] + O2[c] = 2 H2O[c] + NAD+[c] + provitamin D3[c]
Left to rightBalancedEC 1.14.19.20Cholesterol biosynthesis 2Human-GEM MAR01557
H+[c] + lathosterol[c] + NADPH[c] + O2[c] = 2 H2O[c] + NADP+[c] + provitamin D3[c]
Left to rightBalancedEC 1.14.19.20Cholesterol biosynthesis 2Human-GEM MAR01558
(15Z)-tetracosenoylcarnitine[c] = (15Z)-tetracosenoylcarnitine[m]
ReversibleBalancedTransportEC 1.14.13.39Fatty acid oxidationHuman-GEM MAR01559
H2O[e] + Glycogen, Structure 4 (Glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})[e] = glucose[e] + Glycogen, Structure 5 (Glycogenin-2[1,4-Glc])[e]
Left to rightBalancedEC 3.2.1.10Starch and sucrose metabolismHuman-GEM MAR01560
octanoyl-CoA[c] = octanoyl-CoA[x]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01561
oleoyl-CoA[c] = oleoyl-CoA[x]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01562
4-oxo-13-cis-retinoate[c] = 4-oxo-13-cis-retinoate[n]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01563
13-cis-oxo-retinoate[c] = 13-cis-oxo-retinoate[n]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01564
H+[c] + NADPH[c] + provitamin D3[c] = cholesterol[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.21Cholesterol biosynthesis 2Human-GEM MAR01565
oxalate[x] = oxalate[c]
Left to rightBalancedTransportEC 4.1.1.23Transport reactionsHuman-GEM MAR01566
5beta-cholestane-3alpha,7alpha,26-triol[m] + H+[m] + NADPH[m] + O2[m] = 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + 2 H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Bile acid biosynthesisHuman-GEM MAR01567
acetaldehyde[c] + H2O[c] + NAD+[c] = acetate[c] + 2 H+[c] + NADH[c]
Left to rightBalancedEC 1.2.1.4, 1.2.1.5Pyruvate metabolismHuman-GEM MAR01568
24-hydroxycholesterol[r] + H+[r] + NADPH[r] + O2[r] = cholest-5-ene-3beta,7alpha,24(S)-triol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.15.15Bile acid biosynthesisHuman-GEM MAR01569
H+[c] + NADPH[c] + zymosterol[c] = cholestenol[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.72Cholesterol metabolismHuman-GEM MAR01570
cholesterol[r] + H+[r] + NADPH[r] + O2[r] = 24-hydroxycholesterol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.25Bile acid biosynthesisHuman-GEM MAR01571
HMG-CoA[c] = HMG-CoA[m]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01572
acetoacetyl-CoA[m] + acetyl-CoA[m] + H2O[m] = CoA[m] + H+[m] + HMG-CoA[m]
Left to rightBalancedEC 2.3.3.10Terpenoid backbone biosynthesisHuman-GEM MAR01573
26-hydroxycholesterol[r] + H+[r] + NADPH[r] + O2[r] = cholest-5-ene-3beta,7alpha,27-triol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.29Bile acid biosynthesisHuman-GEM MAR01574
20-OH-LTB4[r] + NADPH[r] + 1.5 O2[r] = 20-COOH-LTB4[r] + 2 H2O[r] + NADP+[r]
Left to rightBalancedEicosanoid metabolismHuman-GEM MAR01575
acetoacetate[m] + ATP[m] + CoA[m] = acetoacetyl-CoA[m] + AMP[m] + PPi[m]
Left to rightBalancedEC 6.2.1.16Cholesterol metabolismHuman-GEM MAR01576
HMG-CoA[m] = acetoacetate[m] + acetyl-CoA[m]
Left to rightBalancedEC 4.1.3.4Cholesterol metabolismHuman-GEM MAR01577
cholesterol[m] + H+[m] + NADPH[m] + O2[m] = 20-hydroxycholesterol[m] + H2O[m] + NADP+[m]
ReversibleBalancedCholesterol metabolismHuman-GEM MAR01578
phosphatidate-LD-TAG pool[c] = phosphatidate-LD-TAG pool[r]
ReversibleBalance undeterminableTransportTransport reactionsHuman-GEM MAR01579
phosphatidate-LD-TAG pool[c] = phosphatidate-LD-TAG pool[g]
ReversibleBalance undeterminableTransportTransport reactionsHuman-GEM MAR01580
cholesterol[r] + H+[r] + NADPH[r] + O2[r] = 7alpha-hydroxycholesterol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.23Bile acid biosynthesisHuman-GEM MAR01581