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Subsystem: Bile acid biosynthesis Remove
1–50 of 256 reactions in Bile acid biosynthesis
25(R)DHCA-CoA[x] + 0.5 O2[x] = 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA[x] + H2O[x]
Left to rightBalancedEC 5.1.99.4Human-GEM MAR00069
25(R)DHCA-CoA[r] + 0.5 O2[r] = 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA[r] + H2O[r]
Left to rightBalancedEC 5.1.99.4Human-GEM MAR00070
25(R)THCA-CoA[r] = 25(S)THCA-CoA[r]
Left to rightBalancedEC 5.1.99.4Human-GEM MAR00071
choloyl-CoA[x] + glycine[x] = CoA[x] + glycocholate[x]
Left to rightBalancedEC 2.3.1.65Human-GEM MAR00083
glycine[x] + chenodeoxyglycocholoyl-CoA[x] = CoA[x] + glycochenodeoxycholate[x]
Left to rightBalancedEC 2.3.1.65
chenodeoxycholoyl-CoA[x] + glycine[x] = CoA[x] + glycochenodeoxycholate[x]
Left to rightBalancedEC 2.3.1.65Human-GEM MAR00085
(24R,25R)3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA[x] + 2 H+[x] + 2 NADPH[x] + O2[x] = 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA[x] + 3 H2O[x] + 2 NADP+[x]
Left to rightBalancedHuman-GEM MAR01456
5beta-cholestane-3alpha,7alpha,26-triol[m] + H+[m] + NADPH[m] + O2[m] = 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + 2 H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01567
24-hydroxycholesterol[r] + H+[r] + NADPH[r] + O2[r] = cholest-5-ene-3beta,7alpha,24(S)-triol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01569
cholesterol[r] + H+[r] + NADPH[r] + O2[r] = 24-hydroxycholesterol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.25Human-GEM MAR01571
26-hydroxycholesterol[r] + H+[r] + NADPH[r] + O2[r] = cholest-5-ene-3beta,7alpha,27-triol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.29Human-GEM MAR01574
cholesterol[r] + H+[r] + NADPH[r] + O2[r] = 7alpha-hydroxycholesterol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.23Human-GEM MAR01581
7alpha-hydroxycholesterol[r] + NAD+[r] = 7alpha-hydroxycholest-4-en-3-one[r] + H+[r] + NADH[r]
Left to rightBalancedEC 1.1.1.181Human-GEM MAR01584
7alpha-hydroxycholesterol[r] + NADP+[r] = 7alpha-hydroxycholest-4-en-3-one[r] + H+[r] + NADPH[r]
Left to rightBalancedEC 1.1.1.181Human-GEM MAR01585
7alpha-hydroxycholest-4-en-3-one[r] + H+[r] + NADPH[r] + O2[r] = 7alpha,12alpha-dihydroxycholest-4-en-3-one[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.139Human-GEM MAR01589
7alpha-hydroxycholest-4-en-3-one[r] + H+[r] + NADH[r] + O2[r] = 7alpha,12alpha-dihydroxycholest-4-en-3-one[r] + H2O[r] + NAD+[r]
Left to rightBalancedEC 1.14.14.139Human-GEM MAR01590
7alpha,12alpha-dihydroxycholest-4-en-3-one[c] + H+[c] + NADPH[c] = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.3, 1.3.99.6Human-GEM MAR01595
7alpha,12alpha-dihydroxy-5beta-cholestan-3-one[c] + H+[c] + NADH[c] = 5beta-cholestan-3alpha,7alpha,12alpha-triol[c] + NAD+[c]
Left to rightBalancedEC 1.1.1.50Human-GEM MAR01598
7alpha,12alpha-dihydroxy-5beta-cholestan-3-one[c] + H+[c] + NADPH[c] = 5beta-cholestan-3alpha,7alpha,12alpha-triol[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.50, 1.1.1.213Human-GEM MAR01599
5beta-cholestan-3alpha,7alpha,12alpha-triol[c] + H+[c] + NADPH[c] + O2[c] = 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01604
5beta-cholestan-3alpha,7alpha,12alpha-triol[m] + H+[m] + NADPH[m] + O2[m] = 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01605
5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol[c] + NAD+[c] = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al[c] + H+[c] + NADH[c]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01608
5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol[m] + NAD+[m] = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al[m] + H+[m] + NADH[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01609
5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol[m] + NADP+[m] = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al[m] + H+[m] + NADPH[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01610
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al[c] + H2O[c] + NAD+[c] = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate[c] + 2 H+[c] + NADH[c]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01611
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al[m] + NADH[m] + O2[m] = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate[m] + H2O[m] + NAD+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01613
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al[m] + NADPH[m] + O2[m] = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01614
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate[r] + ATP[r] + CoA[r] = 25(R)THCA-CoA[r] + AMP[r] + PPi[r]
Left to rightBalancedEC 6.2.1.7Human-GEM MAR01624
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate[x] + ATP[x] + CoA[x] = 25(R)THCA-CoA[x] + AMP[x] + PPi[x]
Left to rightBalancedEC 6.2.1.7Human-GEM MAR01625
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate[c] + ATP[c] + CoA[c] = 25(R)THCA-CoA[c] + AMP[c] + PPi[c]
Left to rightBalancedEC 6.2.1.7Human-GEM MAR01627
25(R)THCA-CoA[x] = 25(S)THCA-CoA[x]
Left to rightBalancedEC 5.1.99.4Human-GEM MAR01632
25(S)THCA-CoA[x] + FADH2[x] + O2[x] = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA[x] + FAD[x] + 2 H2O[x]
Left to rightBalancedEC 1.3.3.6, 1.17.99.-Human-GEM MAR01638
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA[x] + H2O[x] = (24R,25R)3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA[x]
Left to rightBalancedEC 4.2.1.107Human-GEM MAR01642
(24R,25R)3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA[x] + NAD+[x] = 3alpha,7alpha,12alpha-trihydroxy-5beta-24-oxocholestanoyl-CoA[x] + H+[x] + NADH[x]
Left to rightBalancedEC 1.1.1.35, 1.1.1.211Human-GEM MAR01646
3alpha,7alpha,12alpha-trihydroxy-5beta-24-oxocholestanoyl-CoA[x] + CoA[x] = choloyl-CoA[x] + propanoyl-CoA[x]
Left to rightBalancedEC 2.3.1.176, 2.3.1.16Human-GEM MAR01652
ATP[c] + choloyl-CoA[c] + H2O[c] = ADP[c] + choloyl-CoA[x] + H+[c] + Pi[c]
Left to rightBalancedTransportHuman-GEM MAR01659
choloyl-CoA[c] + H2O[c] = cholate[c] + CoA[c] + H+[c]
Left to rightBalancedEC 3.1.2.27Human-GEM MAR01660
choloyl-CoA[x] + H2O[x] = cholate[x] + CoA[x] + H+[x]
Left to rightBalancedEC 3.1.2.27Human-GEM MAR01663
choloyl-CoA[x] + taurine[x] = CoA[x] + taurocholate[x]
Left to rightBalancedEC 2.3.1.65Human-GEM MAR01667
choloyl-CoA[c] + taurine[c] = CoA[c] + taurocholate[c]
Left to rightBalancedEC 2.3.1.65Human-GEM MAR01668
choloyl-CoA[c] + glycine[c] = CoA[c] + glycocholate[c]
Left to rightBalancedEC 2.3.1.65Human-GEM MAR01670
7alpha-hydroxycholest-4-en-3-one[c] + H+[c] + NADPH[c] = 7alpha-hydroxy-5beta-cholestan-3-one[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.3, 1.3.99.6Human-GEM MAR01673
7alpha-hydroxy-5beta-cholestan-3-one[c] + H+[c] + NADPH[c] = 5beta-cholestane-3alpha,7alpha-diol[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.213, 1.1.1.50Human-GEM MAR01676
7alpha-hydroxy-5beta-cholestan-3-one[c] + H+[c] + NADH[c] = 5beta-cholestane-3alpha,7alpha-diol[c] + NAD+[c]
Left to rightBalancedEC 1.1.1.50Human-GEM MAR01678
5beta-cholestane-3alpha,7alpha-diol[c] + H+[c] + NADPH[c] + O2[c] = 5beta-cholestane-3alpha,7alpha,26-triol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01681
5beta-cholestane-3alpha,7alpha-diol[m] + H+[m] + NADPH[m] + O2[m] = 5beta-cholestane-3alpha,7alpha,26-triol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01682
3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[c] + H+[c] + NADH[c] = 5beta-cholestane-3alpha,7alpha,26-triol[c] + NAD+[c]
ReversibleBalancedEC 1.1.1.1Human-GEM MAR01684
5beta-cholestane-3alpha,7alpha,26-triol[m] + NADP+[m] = 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + H+[m] + NADPH[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01685
5beta-cholestane-3alpha,7alpha-diol[m] + H+[m] + NADPH[m] + O2[m] = 5beta-cholestane-3alpha,7alpha,27-triol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01687
5beta-cholestane-3alpha,7alpha,27-triol[m] + NAD+[m] = 3alpha,7alpha-dihydroxy-5beta-cholestan-27-al[m] + H+[m] + NADH[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01689