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Subsystem: Cholesterol biosynthesis 3 (Kandustch-Russell pathway) Remove
16 reactions in Cholesterol biosynthesis 3 (Kandustch-Russell pathway)
H+[c] + lanosterol[c] + NADPH[c] = 24,25-dihydrolanosterol[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.72Human-GEM MAR01535
24,25-dihydrolanosterol[c] + H+[c] + NADPH[c] + O2[c] = 4,4-dimethyl-14alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.154Human-GEM MAR01536
4,4-dimethyl-14alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4,4-dimethyl-14alpha-formyl-5alpha-cholesta-8-en-3beta-ol[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.154Human-GEM MAR01538
4,4-dimethyl-14alpha-formyl-5alpha-cholesta-8-en-3beta-ol[c] + NADPH[c] + O2[c] = 4,4-dimethyl-5alpha-cholesta-8,14-dien-3-beta-ol[c] + formate[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.154Human-GEM MAR01539
4,4-dimethyl-5alpha-cholesta-8,14-dien-3-beta-ol[c] + H+[c] + NADPH[c] = 4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.70Human-GEM MAR01540
4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01543
4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-formyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01544
4alpha-formyl-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01545
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol[c] + NADP+[c] = 4alpha-methyl-5alpha-cholesta-8-en-3-one[c] + CO2[c] + H+[c] + NADPH[c]
Left to rightBalancedEC 1.1.1.170Human-GEM MAR01546
4alpha-methyl-5alpha-cholesta-8-en-3-one[c] + H+[c] + NADPH[c] = 4alpha-methyl-cholesta-8-enol[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.270Human-GEM MAR01547
4alpha-methyl-cholesta-8-enol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01548
4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-formyl-5alpha-cholesta-8-en-3beta-ol[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01549
4alpha-formyl-5alpha-cholesta-8-en-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01550
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol[c] + NADP+[c] = 5alpha-cholesta-8-en-3-one[c] + CO2[c] + H+[c] + NADPH[c]
Left to rightBalancedEC 1.1.1.170Human-GEM MAR01551
5alpha-cholesta-8-en-3-one[c] + H+[c] + NADPH[c] = cholestenol[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.270Human-GEM MAR01552
cholestenol[c] = lathosterol[c]
Left to rightBalancedEC 5.3.3.5Human-GEM MAR01553