Loading the page.
Subsystem: Eicosanoid metabolism Remove
1–50 of 60 reactions in Eicosanoid metabolism
20-OH-LTB4[r] + NADPH[r] + 1.5 O2[r] = 20-COOH-LTB4[r] + 2 H2O[r] + NADP+[r]
Left to rightBalancedHuman-GEM MAR01575
2-arachidonoylglycerol[r] + O2[r] = 12-hydroperoxyeicosatetraenoate-glyceryl-ester[r]
Left to rightBalancedEC 1.14.99.1Human-GEM MAR03006
1-lyso-2-arachidonoyl-phosphatidate[g] + H2O[g] = 2-arachidonoylglycerol[g] + Pi[g]
ReversibleBalancedEC 3.1.3.4Human-GEM MAR03010
1-lyso-2-arachidonoyl-phosphatidate[r] + H2O[r] = 2-arachidonoylglycerol[r] + Pi[r]
ReversibleBalancedEC 3.1.3.4Human-GEM MAR03012
prostaglandin E2[m] = H2O[m] + prostaglandin A2[m]
ReversibleBalancedHuman-GEM MAR03016
6,7-dihydro-5-oxo-12-epi-LTB4[m] + ATP[m] + CoA[m] = 5-oxo-12(R)-hydroxy-eicosa-(8E,10E,14Z)-trienoyl-CoA[m] + AMP[m] + PPi[m]
Left to rightBalancedEC 6.2.1.3Human-GEM MAR03801
6,7-dihydro-5-oxo-12-epi-LTB4[r] + ATP[r] + CoA[r] = 5-oxo-12(R)-hydroxy-eicosa-(8E,10E,14Z)-trienoyl-CoA[r] + AMP[r] + PPi[r]
Left to rightBalancedEC 6.2.1.3Human-GEM MAR03803
6,7-dihydro-5-oxo-12-epi-LTB4[x] + ATP[x] + CoA[x] = 5-oxo-12(R)-hydroxy-eicosa-(8E,10E,14Z)-trienoyl-CoA[x] + AMP[x] + PPi[x]
Left to rightBalancedEC 6.2.1.3Human-GEM MAR03805
3(S),12(R)-dihydroxy-5-oxo-eicosa-(8E,10E,14Z)-trienoyl-CoA[c] + NAD+[c] = 3,5-dioxo-12(R)-hydroxy-eicosa-(8E,10E,14Z)-trienoyl-CoA[c] + H+[c] + NADH[c]
ReversibleBalancedEC 1.1.1.35Human-GEM MAR03808
3-oxo-10(R)-hydroxy-octadeca-(6E,8E,12Z)-trienoyl-CoA[c] + H2O[c] = 3-oxo-10(R)-hydroxy-octadeca-(6E,8E,12Z)-trienoate[c] + CoA[c] + H+[c]
ReversibleBalancedEC 3.1.2.2Human-GEM MAR03810
3(S),12(S)-dihydroxy-5-oxo-eicosa-(8E,10E,14Z)-trienoyl-CoA[c] + NAD+[c] = 3,5-dioxo-12(S)-hydroxy-eicosa-(8E,10E,14Z)-trienoyl-CoA[c] + H+[c] + NADH[c]
ReversibleBalancedEC 1.1.1.35Human-GEM MAR03812
3-oxo-10(S)-hydroxy-octadeca-(6E,8E,12Z)-trienoyl-CoA[c] + H2O[c] = 3-oxo-10(S)-hydroxy-octadeca-(6E,8E,12Z)-trienoate[c] + CoA[c] + H+[c]
ReversibleBalancedEC 3.1.2.2Human-GEM MAR03814
prostaglandin J2[m] = delta-12-prostaglandin J2[m]
ReversibleBalancedEC 1.5.1.38, 1.5.1.39, 1.5.1.41Human-GEM MAR03834
prostaglandin J2[r] = delta-12-prostaglandin J2[r]
ReversibleBalancedHuman-GEM MAR03836
10,11-dihydro-12-epi-LTB4[c] + H+[c] + NADPH[c] + O2[c] = 20-OH-10,11-dihydro-LTB4[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR03840
10,11-dihydro-12-epi-LTB4[r] + H+[r] + NADPH[r] + O2[r] = 20-OH-10,11-dihydro-LTB4[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR03842
3(S),10(R)-OH-octadeca-6-trans-4,12-cis-trienoyl-CoA[c] + H2O[c] = 3(S),10(R)-OH-octadeca-6-trans-4,12-cis-trienoate[c] + CoA[c] + H+[c]
ReversibleBalancedEC 3.1.2.2Human-GEM MAR03844
10,11-dihydro-12-epi-LTB4[m] + ATP[m] + CoA[m] = 10,11-dihydro-LTB4-CoA[m] + AMP[m] + PPi[m]
Left to rightBalancedEC 6.2.1.3Human-GEM MAR03846
10,11-dihydro-12-epi-LTB4[r] + ATP[r] + CoA[r] = 10,11-dihydro-LTB4-CoA[r] + AMP[r] + PPi[r]
Left to rightBalancedEC 6.2.1.3Human-GEM MAR03872
10,11-dihydro-12-epi-LTB4[x] + ATP[x] + CoA[x] = 10,11-dihydro-LTB4-CoA[x] + AMP[x] + PPi[x]
Left to rightBalancedEC 6.2.1.3Human-GEM MAR03874
3(S),5(S),12(R)-trihydroxy-eicosa-8-trans-6,14-cis-trienoyl-CoA[c] + NAD+[c] = 3-oxo-5(S),12(R)-dihydroxy-eicosa-8-trans-6,14-cis-trienoyl-CoA[c] + H+[c] + NADH[c]
ReversibleBalancedEC 1.1.1.35Human-GEM MAR03876
3 arachidonate[c] + 5 H+[c] + 5 O2-[c] = 3 9-peroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate[c] + 4 H2O[c]
Left to rightBalancedHuman-GEM MAR03878
3 arachidonate[c] + 5 H+[c] + 5 O2-[c] = 3 12-peroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate[c] + 4 H2O[c]
Left to rightBalancedHuman-GEM MAR03880
4 arachidonate[c] + 5 O2[c] = 4 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate[c] + 2 H2O[c]
Left to rightBalancedHuman-GEM MAR03882
3 arachidonate[c] + 5 H+[c] + 5 O2-[c] = 3 11-peroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate[c] + 4 H2O[c]
Left to rightBalancedHuman-GEM MAR03884
15(S)-HPETE[c] = 15(S)-HEPE[c] + H2O[c]
ReversibleBalancedEC 3.1.2.2Human-GEM MAR03898
(18R)-HEPE[n] + O2[n] = 5,6-epoxy,(18R)-HEPE[n] + H2O[n]
Left to rightBalancedEC 1.13.11.34Human-GEM MAR03900
9-deoxy-delta12-PGD2[m] + GSH[m] = S-(9-deoxy-delta12-PGD2)-glutathione[m]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR03938
9-deoxy-delta12-PGD2[r] + GSH[r] = S-(9-deoxy-delta12-PGD2)-glutathione[r]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR03941
GSH[m] + prostaglandin J2[m] = S-(PGJ2)-glutathione[m]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR03942
GSH[r] + prostaglandin J2[r] = S-(PGJ2)-glutathione[r]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR03943
delta-12-prostaglandin J2[m] + GSH[m] = S-(9-deoxy-delta9,12-PGD2)-glutathione[m]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR03945
delta-12-prostaglandin J2[r] + GSH[r] = S-(9-deoxy-delta9,12-PGD2)-glutathione[r]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR03961
2 H+[r] + prostaglandin D2[r] = 9-deoxy-delta12-PGD2[r] + H2O[r]
ReversibleUnbalancedEC 1.13.11.34Human-GEM MAR03962
GSH[m] + prostaglandin A2[m] = S-(PGA2)-glutathione[m]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR03963
GSH[r] + prostaglandin A2[r] = S-(PGA2)-glutathione[r]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR03973
GSH[m] + prostaglandin A1[m] = S-(PGA1)-glutathione[m]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR03976
GSH[r] + prostaglandin A1[r] = S-(PGA1)-glutathione[r]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR03978
18-CoA-18-oxo-dinor-LTB4[c] + H2O[c] = CoA[c] + H+[c] + omega-carboxy-trinor-LTB4[c]
ReversibleBalancedEC 3.1.2.2Human-GEM MAR03981
20-CoA-20-oxo-18r-hydroxy-LTB4[c] + NAD+[c] = 18,20-dioxo-20-CoA-LTB4[c] + H+[c] + NADH[c]
ReversibleBalancedEC 1.1.1.35Human-GEM MAR03983
prostaglandin H1[n] = prostaglandin E1[n]
ReversibleBalancedEC 5.3.99.3Human-GEM MAR03985
12-oxo-20-carboxy-LTB4[m] + H+[m] + NADPH[m] = 12-oxo-10,11-dihydro-20-COOH-LTB4[m] + NADP+[m]
ReversibleBalancedEC 1.1.1.184Human-GEM MAR03990
12-oxo-20-carboxy-LTB4[x] + H+[x] + NADPH[x] = 12-oxo-10,11-dihydro-20-COOH-LTB4[x] + NADP+[x]
ReversibleBalancedEC 1.1.1.184Human-GEM MAR03994
arachidonate[c] + O2[c] = 12(R)-HPETE[c]
Left to rightBalancedEC 1.13.11.-Human-GEM MAR08545
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate[c] + H+[c] + NADPH[c] = NADP+[c] + prostaglandin E1[c]
ReversibleBalancedEC 1.1.1.197Human-GEM MAR08546
H2O[c] + leukotriene C4[c] = glycine[c] + leukotriene F4[c]
ReversibleBalancedHuman-GEM MAR08547
H2O[r] + leukotriene C4[r] = glutamate[r] + LTD4[r]
ReversibleBalancedEC 2.3.2.2Human-GEM MAR08548
H2O[c] + leukotriene F4[c] = glutamate[c] + leukotriene E4[c]
ReversibleBalancedHuman-GEM MAR08549
GSH[r] + leukotriene A4[r] = leukotriene C4[r]
Left to rightBalancedEC 4.4.1.20Human-GEM MAR08550
H2O[c] + LTD4[c] = glycine[c] + leukotriene E4[c]
ReversibleBalancedHuman-GEM MAR08552