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Subsystem: Cholesterol metabolism Remove
1–50 of 60 reactions in Cholesterol metabolism
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol[r] + H+[r] + NADPH[r] = 14-demethyllanosterol[r] + NADP+[r]
Left to rightBalancedEC 1.3.1.70Human-GEM MAR00101
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol[r] + NADP+[r] = 3-keto-4-methylzymosterol[r] + CO2[r] + H+[r] + NADPH[r]
Left to rightBalancedEC 1.1.1.170Human-GEM MAR00113
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol[r] + NAD+[r] = 3-keto-4-methylzymosterol[r] + CO2[r] + H+[r] + NADH[r]
Left to rightBalancedEC 1.1.1.170Human-GEM MAR00114
H+[r] + NADPH[r] + Zymosterol Intermediate 2[r] = NADP+[r] + zymosterol[r]
Left to rightBalancedEC 4.2.1.17Human-GEM MAR00115
14-demethyllanosterol[r] + 3 H+[r] + 3 NADPH[r] + 3 O2[r] = 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol[r] + 4 H2O[r] + 3 NADP+[r]
Left to rightBalancedEC 4.2.1.17Human-GEM MAR00116
3-keto-4-methylzymosterol[r] + NADP+[r] + O2[r] = CO2[r] + H+[r] + NADPH[r] + Zymosterol Intermediate 2[r]
Left to rightBalancedEC 1.1.1.170Human-GEM MAR00117
3-keto-4-methylzymosterol[r] + NAD+[r] + O2[r] = CO2[r] + H+[r] + NADH[r] + Zymosterol Intermediate 2[r]
Left to rightBalancedHuman-GEM MAR00118
desmosterol[r] + FADH2[r] = cholesterol[r] + FAD[r]
Left to rightBalancedEC 2.3.1.42Human-GEM MAR00222
7-dehydrodesmosterol[r] + H+[r] + NADPH[r] = desmosterol[r] + NADP+[r]
Left to rightBalancedEC 1.3.1.21Human-GEM MAR00227
H+[r] + NADPH[r] + provitamin D3[r] = cholesterol[r] + NADP+[r]
Left to rightBalancedEC 1.3.1.21Human-GEM MAR00228
dimethylallyl-PP[x] + isopentenyl-pPP[x] = geranyl-PP[x] + PPi[x]
Left to rightBalancedEC 2.5.1.1Human-GEM MAR00285
(R)-5-diphosphomevalonate[x] + ATP[x] = ADP[x] + CO2[x] + isopentenyl-pPP[x] + Pi[x]
Left to rightBalancedEC 4.1.1.33Human-GEM MAR00441
zymosterol[r] = 5alpha-cholesta-7,24-dien-3beta-ol[r]
Left to rightBalancedEC 5.3.3.5Human-GEM MAR00443
geranyl-PP[x] + isopentenyl-pPP[x] = farnesyl-PP[x] + PPi[x]
Left to rightBalancedEC 2.5.1.10Human-GEM MAR01397
acetoacetyl-CoA[c] + acetyl-CoA[c] + H2O[c] = CoA[c] + H+[c] + HMG-CoA[c]
Left to rightBalancedEC 2.3.3.10Human-GEM MAR01437
2 H+[r] + HMG-CoA[r] + 2 NADPH[r] = (R)-mevalonate[r] + CoA[r] + 2 NADP+[r]
Left to rightBalancedEC 1.1.1.88Human-GEM MAR01446
HMG-CoA[x] = acetoacetate[x] + acetyl-CoA[x]
Left to rightBalancedEC 4.1.3.4Human-GEM MAR01449
(R)-5-diphosphomevalonate[c] + ATP[c] = ADP[c] + CO2[c] + isopentenyl-pPP[c] + Pi[c]
Left to rightBalancedEC 4.1.1.33Human-GEM MAR01451
dimethylallyl-PP[c] + isopentenyl-pPP[c] = geranyl-PP[c] + PPi[c]
Left to rightBalancedEC 2.5.1.1, 2.5.1.10, 2.5.1.29Human-GEM MAR01457
geranyl-PP[c] + isopentenyl-pPP[c] = farnesyl-PP[c] + PPi[c]
Left to rightBalancedEC 2.5.1.1, 2.5.1.10, 2.5.1.29Human-GEM MAR01460
isopentenyl-pPP[x] = dimethylallyl-PP[x]
ReversibleBalancedEC 5.3.3.2Human-GEM MAR01468
2 H+[c] + lanosterol[c] + 3 NADPH[c] + 3 O2[c] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol[c] + formate[c] + 4 H2O[c] + 3 NADP+[c]
Left to rightBalancedEC 1.14.14.1Human-GEM MAR01497
squalene 2,3-oxide[r] = lanosterol[r]
Left to rightBalancedEC 5.4.99.7Human-GEM MAR01498
5alpha-cholesta-7,24-dien-3beta-ol[r] + H+[r] + NADPH[r] + O2[r] = 7-dehydrodesmosterol[r] + 2 H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.19.20Human-GEM MAR01508
H+[r] + lathosterol[r] + NADPH[r] + O2[r] = 2 H2O[r] + NADP+[r] + provitamin D3[r]
Left to rightBalancedEC 1.14.19.20Human-GEM MAR01510
(R)-mevalonate[x] + ATP[x] = (R)-5-phosphomevalonate[x] + ADP[x] + H+[x]
Left to rightBalancedEC 2.7.1.36Human-GEM MAR01520
H+[c] + NADH[c] + O2[c] + provitamin D3[c] = 27alpha-hydroxy-7-dehydrocholesterol[c] + H2O[c] + NAD+[c]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01531
H+[c] + NADPH[c] + zymosterol[c] = cholestenol[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.72Human-GEM MAR01570
acetoacetate[m] + ATP[m] + CoA[m] = acetoacetyl-CoA[m] + AMP[m] + PPi[m]
Left to rightBalancedEC 6.2.1.16Human-GEM MAR01576
HMG-CoA[m] = acetoacetate[m] + acetyl-CoA[m]
Left to rightBalancedEC 4.1.3.4Human-GEM MAR01577
cholesterol[m] + H+[m] + NADPH[m] + O2[m] = 20-hydroxycholesterol[m] + H2O[m] + NADP+[m]
ReversibleBalancedHuman-GEM MAR01578
(R)-5-phosphomevalonate[x] + ATP[x] = (R)-5-diphosphomevalonate[x] + ADP[x]
Left to rightBalancedEC 2.7.4.2Human-GEM MAR01628
H+[r] + NADPH[r] + O2[r] + squalene[r] = H2O[r] + NADP+[r] + squalene 2,3-oxide[r]
Left to rightBalancedEC 1.14.14.17Human-GEM MAR01714
2 farnesyl-PP[r] + H+[r] + NADPH[r] = NADP+[r] + 2 PPi[r] + squalene[r]
Left to rightBalancedEC 2.5.1.21Human-GEM MAR01715
2 farnesyl-PP[r] = PPi[r] + presqualene-PP[r]
Left to rightBalancedEC 2.5.1.21Human-GEM MAR02026
H+[r] + NADPH[r] + presqualene-PP[r] = NADP+[r] + PPi[r] + squalene[r]
Left to rightBalancedEC 2.5.1.21Human-GEM MAR02147
2 H+[r] + lanosterol[r] + 3 NADPH[r] + 3 O2[r] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol[r] + formate[r] + 4 H2O[r] + 3 NADP+[r]
Left to rightBalancedEC 1.14.14.154Human-GEM MAR02200
lathosterol[r] + NADP+[r] = 5alpha-cholesta-7,24-dien-3beta-ol[r] + H+[r] + NADPH[r]
ReversibleBalancedEC 1.3.1.72Human-GEM MAR02206
14-demethyllanosterol[r] + H+[r] + NADPH[r] + 2 O2[r] = 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol[r] + 2 H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR02300
3-keto-4-methylzymosterol[r] + 3 H+[r] + NADP+[r] = 4alpha-methylzymosterol[r] + NADPH[r]
ReversibleUnbalancedEC 1.1.1.270Human-GEM MAR02301
4alpha-methylzymosterol[r] + 2 H2O[r] = CO2[r] + 6 H+[r] + zymosterol[r]
Left to rightUnbalancedHuman-GEM MAR02302
H+[r] + NADPH[r] + zymosterol[r] = cholestenol[r] + NADP+[r]
ReversibleBalancedEC 1.3.1.72Human-GEM MAR02337
lathosterol[r] = cholestenol[r]
ReversibleBalancedEC 5.3.3.5Human-GEM MAR02339
7-dehydrodesmosterol[n] + H+[n] + NADPH[n] = desmosterol[n] + NADP+[n]
ReversibleBalancedEC 1.3.1.21Human-GEM MAR03061
acetoacetyl-CoA[x] + CoA[x] = 2 acetyl-CoA[x]
ReversibleBalancedEC 2.3.1.9Human-GEM MAR03105
desmosterol[n] + H+[n] + NADPH[n] = cholesterol[n] + NADP+[n]
ReversibleBalancedEC 1.1.1.35Human-GEM MAR03419
H+[c] + NADPH[c] + 4,4-Dimethylcholesta-8(9),14-Dien-3Beta-Ol[c] = 4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol[c] + NADP+[c]
ReversibleBalancedEC 1.3.1.70Human-GEM MAR03420
H+[r] + NADPH[r] + 4,4-Dimethylcholesta-8(9),14-Dien-3Beta-Ol[r] = 4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol[r] + NADP+[r]
ReversibleBalancedEC 1.3.1.70Human-GEM MAR03434
3 24,25-dihydrolanosterol[c] + CO2[c] = 2 H2O[c] + 3 4,4-Dimethylcholesta-8(9),14-Dien-3Beta-Ol[c] + 4 One Carbon Unit[c]
ReversibleBalancedHuman-GEM MAR03536
CO2[c] + 3 lanosterol[c] = 3 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol[c] + 2 H2O[c] + 4 One Carbon Unit[c]
Left to rightBalancedHuman-GEM MAR03598