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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1–50 of 18,558 reactions from Rhea

pentanamide + H2O = pentanoate + NH4(+)
Direction not assertedBalancedRhea 10000
benzyl isothiocyanate = benzyl thiocyanate
Direction not assertedBalancedRhea 10004
a hydroperoxide + [protein]-dithiol = [protein]-disulfide + an alcohol + H2O
Direction not assertedBalance undeterminableRhea 10008
(R)-6-hydroxynicotine + O2 + H2O = 6-hydroxypseudooxynicotine + H2O2
Direction not assertedBalancedRhea 10012
O-sinapoylcholine + H2O = (E)-sinapate + choline + H(+)
Direction not assertedBalancedRhea 10016
L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)
Direction not assertedBalancedRhea 10020
L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 10024

D-glutamate + O2 + H2O = 2-oxoglutarate + H2O2 + NH4(+)

Left to rightBalancedRhea 10028

[protein]-C-terminal-L-glutamine + H2O = [protein]-C-terminal-L-glutamate + NH4(+)

Direction not assertedBalance undeterminableRhea 10032

4-hydroxy-3-methoxy-benzenemethanol + O2 = vanillin + H2O2

Direction not assertedBalancedRhea 10036

adenosine 3',5'-bisphosphate + H2O = AMP + phosphate

Left to rightBalancedRhea 10040

cyclohexanol + NAD(+) = cyclohexanone + NADH + H(+)

Direction not assertedBalancedRhea 10044

O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)

Direction not assertedBalancedRhea 10048

(2R)-hydroxy-4-methylpentanoate + NAD(+) = 4-methyl-2-oxopentanoate + NADH + H(+)

Direction not assertedBalancedRhea 10052

(3S)-3-aminobutanoyl-CoA = (2E)-butenoyl-CoA + NH4(+)

Direction not assertedBalancedRhea 10056

D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H(+)

Direction not assertedBalancedRhea 10060

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O = 2-methylserine + (6S)-5,6,7,8-tetrahydrofolate

Direction not assertedBalancedRhea 10064

4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP + n H(+)

Direction not assertedBalance undeterminableRhea 10068

N,N-dimethylglycine + S-adenosyl-L-methionine = glycine betaine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 10072

lactose + H2O = beta-D-galactose + D-glucose

Left to rightBalancedRhea 10076

dihydrophloroglucinol + NADP(+) = 1,3,5-trihydroxybenzene + NADPH

Direction not assertedBalancedRhea 10080

3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate + 2 H(+)

Direction not assertedBalancedRhea 10084

sucrose + UDP-alpha-D-galactose = 6(F)-alpha-D-galactosylsucrose + UDP + H(+)

Direction not assertedBalancedRhea 10088

a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate

Direction not assertedBalance undeterminableRhea 10092

a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + S-methyl-5'-thioadenosine + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 10096

a sterol ester + H2O = a sterol + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 10100

gibberellin A20 + 2-oxoglutarate + O2 = gibberellin A1 + succinate + CO2

Direction not assertedBalancedRhea 10104

(7S)-salutaridinol + NADP(+) = salutaridine + NADPH + H(+)

Direction not assertedBalancedRhea 10108

L-homocysteine + L-serine = L,L-cystathionine + H2O

Direction not assertedBalancedRhea 10112

6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH

Direction not assertedBalancedRhea 10116

adenosine in double-stranded RNA + H2O + H(+) = inosine in double-stranded RNA + NH4(+)

Left to rightBalancedRhea 10120

phenylacetone + NADPH + O2 + H(+) = benzyl acetate + NADP(+) + H2O

Direction not assertedBalancedRhea 10124

all-trans-violaxanthin = all-trans-neoxanthin

Direction not assertedBalancedRhea 10128

benzoate + ATP + CoA = benzoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 10132

2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO2

Direction not assertedBalancedRhea 10136

prostaglandin F2alpha + NADP(+) = prostaglandin D2 + NADPH + H(+)

Right to leftBalancedRhea 10140

a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate

Direction not assertedBalance undeterminableRhea 10144

blasticidin S + H2O + H(+) = deaminohydroxyblasticidin S + NH4(+)

Direction not assertedBalancedRhea 10148

hydrogencarbonate + NH4(+) + ATP = carbamoyl phosphate + ADP + H2O + H(+)

Direction not assertedBalancedRhea 10152

dihydrochelirubine + reduced [NADPH--hemoprotein reductase] + O2 = 12-hydroxydihydrochelirubine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 10156

L-iditol + NAD(+) = keto-L-sorbose + NADH + H(+)

Direction not assertedBalancedRhea 10160

(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O

ReversibleBalancedRhea 10164

15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + reduced 2[4Fe-4S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 10168

(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+)

Direction not assertedBalancedRhea 10172

(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) = (R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H(+)

Direction not assertedBalancedRhea 10176

(6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)

Left to rightBalancedRhea 10180

(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O = 3-oxoadipate + H(+)

Direction not assertedBalancedRhea 10184

acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)

Left to rightBalancedRhea 10188

sulfate(out) + ATP + H2O = sulfate(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 10192

(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O

Direction not assertedBalancedRhea 10196

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