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Proteins/UNIPROT:A6XGL0
May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (By similarity). May play a role in spermiogenesis and oogenesis..
Function from UniProtKB (A6XGL0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
19 statements
19 statements · 2 reference databases · Subject: YJEFN3 · Sources: gene ontology, Hetionet
4 names
Resolves to: YJEFN3