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Proteins/UNIPROT:Q9H4L7
Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Combines the ATP-dependent ability to exchange histones, with the chaperone-like ATP-independent activity to deposit histones and assemble nucleosomes. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing..
Function from UniProtKB (Q9H4L7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
42 statements
42 statements · 2 reference databases · Subject: SMARCAD1 · Sources: gene ontology, Hetionet
1 reaction
1 name
Resolves to: SMARCAD1
Rhea RHEA:13065CC BY 4.0Reference data