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Proteins/UNIPROT:Q8N394
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3..
Function from UniProtKB (Q8N394), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 statement
1 statement · 1 reference database · Subject: TMTC2 · Sources: Hetionet
2 reactions
a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate+L-seryl-[protein]3-O-(alpha-D-mannosyl)-L-seryl-[protein]+a di-trans,poly-cis-dolichyl phosphate+hydron
Catalysed by TMTC3 or TMTC1 or TMTC2 or TMEM260 or POMT2 or POMT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17377CC BY 4.0Reference data
a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate+L-threonyl-[protein]3-O-(alpha-D-mannosyl)-L-threonyl-[protein]
2 names
Resolves to: TMTC2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:53396CC BY 4.0Reference data