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Proteins/UNIPROT:P29120

PCSK1

Protein·UNIPROT:P29120

Open in the graph

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, oxytocin, vasopressin, enkephalin, dynorphin, somatostatin, insulin and AGRP..

Function from UniProtKB (P29120), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

obesity due to prohormone convertase I deficiency has a germline basis in PCSK1DiseaseGenCC HGNC:8743|MONDO:0010961Inferred only

Statements

16 statements

16 statements · 4 reference databases · Subject: PCSK1 · Sources: Hetionet, Reactome, UniProt, WikiPathways

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CTNNB1 interacts with PCSK1ProteinHetionet hetionet:interacts:1499-5122Inferred only
PCSK1 interacts with PCSK1NProteinHetionet hetionet:interacts:27344-5122Inferred only
PCSK1 interacts with PMCHProteinHetionet hetionet:interacts:5122-5367Inferred only
PCSK1 interacts with RENProteinHetionet hetionet:interacts:5122-5972Inferred only
PCSK1 participates in GLP 1 from intestine and pancreas and role in glucose homeostasisPathwayWikiPathways WP5452Inferred only
PCSK1 participates in GLP 1 secretion from intestine to portal veinPathwayWikiPathways WP5446Inferred only
PCSK1 participates in Incretin synthesis, secretion, and inactivationPathwayReactome R-HSA-400508Inferred only
PCSK1 participates in Insulin processingPathwayReactome R-HSA-264876Inferred only
PCSK1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
PCSK1 participates in Peptide hormone biosynthesisPathwayReactome R-HSA-209952Inferred only
PCSK1 participates in Peptide hormone metabolismPathwayReactome R-HSA-2980736Inferred only
PCSK1 participates in Prader Willi and Angelman syndromePathwayWikiPathways WP3998Inferred only

Show the remaining 4

PCSK1 participates in Synthesis, secretion, and deacylation of GhrelinPathwayReactome R-HSA-422085Inferred only
PCSK1 participates in Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)PathwayReactome R-HSA-381771Inferred only
PCSK1 participates in Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)PathwayReactome R-HSA-400511Inferred only
PCSK1 requires the cofactor Ca(2+)CompoundUniProt P29120Inferred only

Other names

5 names

Resolves to: PCSK1

Also called: NEC 1NEC1PC1Prohormone convertase 1Proprotein convertase 1

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