Proteins/UNIPROT:Q99705

MCHR1

ProteinUNIPROT:Q99705

G protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C and mobilize intracellular calcium. Predominantly localized within the central nervous system where it regulates various physiological processes including feeding behavior, energy homeostasis, stress/anxiety-related behaviors and sleep..

Function from UniProtKB (Q99705), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

21 statements

21 statements · 4 reference databases · Subject: MCHR1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

IRX1 covaries with MCHR1ProteinHetionet hetionet:covaries:2847-79192Inferred only
EGR1 interacts with MCHR1ProteinHetionet hetionet:interacts:1958-2847Inferred only
MCHR1 interacts with PMCHProteinHetionet hetionet:interacts:2847-5367Inferred only
MCHR1 interacts with ZMYND19ProteinHetionet hetionet:interacts:116225-2847Inferred only
MCHR1 participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
MCHR1 participates in BBSome-mediated cargo-targeting to ciliumPathwayReactome R-HSA-5620922Inferred only
MCHR1 participates in Cargo trafficking to the periciliary membranePathwayReactome R-HSA-5620920Inferred only
MCHR1 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
MCHR1 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
MCHR1 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
MCHR1 participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
MCHR1 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only

Show the remaining 9

MCHR1 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
MCHR1 participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
MCHR1 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
MCHR1 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
MCHR1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
MCHR1 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
MCHR1 regulates positive regulation of calcium ion transportBiological processgene ontology Q99705|GO:0051928Inferred only
MCHR1 regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology Q99705|GO:0007204Inferred only
MCHR1 regulates regulation of feeding behaviorBiological processgene ontology Q99705|GO:0060259Inferred only

Other names

11 names

Resolves to: MCHR1

Also called: G protein-coupled receptor 24GPR24MCH receptor 1MCH-1RMCH-R1MCH1RMCHRMCHR-1SLC-1SLC1Somatostatin receptor-like protein

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