Proteins/UNIPROT:P16519

PCSK2

ProteinUNIPROT:P16519

Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. Mediates the release of insulin from proinsulin..

Function from UniProtKB (P16519), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

6 statements

6 statements · 3 reference databases · Subject: PCSK2 · Sources: Hetionet, Reactome, WikiPathways

Order

PCSK2 interacts with PMCHProteinHetionet hetionet:interacts:5126-5367Inferred only
PCSK2 interacts with SCG5ProteinHetionet hetionet:interacts:5126-6447Inferred only
PCSK2 participates in GLP 1 from intestine and pancreas and role in glucose homeostasisPathwayWikiPathways WP5452Inferred only
PCSK2 participates in Insulin processingPathwayReactome R-HSA-264876Inferred only
PCSK2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
PCSK2 participates in Peptide hormone metabolismPathwayReactome R-HSA-2980736Inferred only

Other names

6 names

Resolves to: PCSK2

Also called: KEX2-like endoprotease 2NEC 2NEC2PC2Prohormone convertase 2Proprotein convertase 2

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