TOP6BL

Non-catalytic component of a topoisomerase 6 complex specifically required for double-strand breaks (DSB) formation that initiate meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (By similarity). Within the complex, TOP6BL may sense specific DNA architectures, such as bendable and underwound DNA for cleavage by SPO11 (By similarity)..

Function from UniProtKB (Q8N6T0), read 2026-09-23. CC BY 4.0.