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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q969R5

L3MBTL2

Protein·UNIPROT:Q969R5

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Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'..

Function from UniProtKB (Q969R5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

34 statements

34 statements · 3 reference databases · Subject: L3MBTL2 · Sources: gene ontology, Hetionet, Reactome

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CBX3 interacts with L3MBTL2ProteinHetionet hetionet:interacts:11335-83746Inferred only
E2F6 interacts with L3MBTL2ProteinHetionet hetionet:interacts:1876-83746Inferred only
L3MBTL2 interacts with H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16ProteinHetionet hetionet:interacts:554313-83746Inferred only
L3MBTL2 interacts with H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16ProteinHetionet hetionet:interacts:121504-83746Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8294-83746Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8363-83746Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8370-83746Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8365-83746Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8359-83746Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8360-83746Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8366-83746Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8361-83746Inferred only

Show the remaining 22

H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8367-83746Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8362-83746Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8364-83746Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with L3MBTL2ProteinHetionet hetionet:interacts:8368-83746Inferred only
HDAC3 interacts with L3MBTL2ProteinHetionet hetionet:interacts:83746-8841Inferred only
MEAF6 interacts with L3MBTL2ProteinHetionet hetionet:interacts:64769-83746Inferred only
MPP3 interacts with L3MBTL2ProteinHetionet hetionet:interacts:4356-83746Inferred only
L3MBTL2 interacts with PCGF6ProteinHetionet hetionet:interacts:83746-84108Inferred only
PHF10 interacts with L3MBTL2ProteinHetionet hetionet:interacts:55274-83746Inferred only
RNF2 interacts with L3MBTL2ProteinHetionet hetionet:interacts:6045-83746Inferred only
STAM2 interacts with L3MBTL2ProteinHetionet hetionet:interacts:10254-83746Inferred only
SUMO2 interacts with L3MBTL2ProteinHetionet hetionet:interacts:6613-83746Inferred only
L3MBTL2 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
L3MBTL2 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
L3MBTL2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
L3MBTL2 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
L3MBTL2 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
L3MBTL2 participates in SUMO E3 ligases SUMOylate target proteinsPathwayReactome R-HSA-3108232Inferred only
L3MBTL2 participates in SUMOylationPathwayReactome R-HSA-2990846Inferred only
L3MBTL2 participates in SUMOylation of chromatin organization proteinsPathwayReactome R-HSA-4551638Inferred only
L3MBTL2 participates in Transcriptional Regulation by E2F6PathwayReactome R-HSA-8953750Inferred only
L3MBTL2 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q969R5|GO:0045892Inferred only

Other names

3 names

Resolves to: L3MBTL2

Also called: 3H-l(3)mbt-like protein 2L(3)mbt-like protein 2

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