Pathway
Negative regulation of NMDA receptor-mediated neuronal transmission
The duration of NMDA receptor-mediated neuronal transmission can be limited by binding of the activated calmodulin to the activated NMDA receptor. In addition to shortening the NMDA channel pore open state, calmodulin interferes with ACTN2-mediated anchoring of NMDA receptors to the postsynaptic density. Protein phosphatases PPM1E and PPM1F dephosphorylate activated calcium/calmodulin-dependent kinases (CaMKs), thus halting CaMK-mediated signaling (Ishida, Okuno et al. 1998, Ishida et al. 1998, Kitani et al. 2003).
REACT:R-HSA-9617324Reactome
What the reference databases state
Statements
21 statements
21 statements · 1 reference database · Subject: Negative regulation of NMDA receptor-mediated neuronal transmission · Sources: Reactome
- ACTN2 participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- CALM1 participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- CAMK1 participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- CAMK2A participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- CAMK2B participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- CAMK2D participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- CAMK2G participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- CAMK4 participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- DLG1 participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- DLG2 participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- DLG3 participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- DLG4 participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
Show the remaining 9
- GRIN1 participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- GRIN2A participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- GRIN2B participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- GRIN2C participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- GRIN2D participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- LRRC7 participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- NEFL participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- PPM1E participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only
- PPM1F participates in Negative regulation of NMDA receptor-mediated neuronal transmissionProteinReactome R-HSA-9617324Inferred only