Proteins/UNIPROT:P12036

NEFH

ProteinUNIPROT:P12036

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)..

Function from UniProtKB (P12036), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Charcot-Marie-Tooth disease axonal type 2CC has a germline basis in NEFHDiseaseGenCC HGNC:7737|MONDO:0014836Inferred only

Statements

15 statements

15 statements · 3 reference databases · Subject: NEFH · Sources: gene ontology, Hetionet, WikiPathways

Order

NEFH covaries with ASCL2ProteinHetionet hetionet:covaries:430-4744Inferred only
NEFH covaries with BAXProteinHetionet hetionet:covaries:4744-581Inferred only
NEFH covaries with C1QL3ProteinHetionet hetionet:covaries:389941-4744Inferred only
NEFH covaries with CTDSP1ProteinHetionet hetionet:covaries:4744-58190Inferred only
EPOP covaries with NEFHProteinHetionet hetionet:covaries:100170841-4744Inferred only
NEFH covaries with PIN1ProteinHetionet hetionet:covaries:4744-5300Inferred only
NEFH interacts with MAPK1ProteinHetionet hetionet:interacts:4744-5594Inferred only
NEFH interacts with NEFLProteinHetionet hetionet:interacts:4744-4747Inferred only
NEFM interacts with NEFHProteinHetionet hetionet:interacts:4741-4744Inferred only
NEFH interacts with PKN1ProteinHetionet hetionet:interacts:4744-5585Inferred only
NEFH interacts with STXBP1ProteinHetionet hetionet:interacts:4744-6812Inferred only
NEFH interacts with UBCProteinHetionet hetionet:interacts:4744-7316Inferred only

Show the remaining 3

NEFH participates in Amyotrophic lateral sclerosis ALS PathwayWikiPathways WP2447Inferred only
NEFH participates in Physico chemical features and toxicity associated pathwaysPathwayWikiPathways WP3680Inferred only
NEFH regulates regulation of organelle transport along microtubuleBiological processgene ontology P12036|GO:1902513Inferred only

Other names

5 names

Resolves to: NEFH

Also called: 200 kDa neurofilament proteinKIAA0845Neurofilament triplet H proteinNF-HNFH

← Every protein Find it in the graph →