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Proteins/UNIPROT:Q8NA29
Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion..
Function from UniProtKB (Q8NA29), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
2 rows
28 statements
28 statements · 4 reference databases · Subject: MFSD2A · Sources: Bgee, gene ontology, Reactome, Rhea
5 reactions
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+sodium(1+)1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+sodium(1+)
Transported by MFSD2A
Reaction pageDirection not assertedBalanced
Rhea RHEA:43856CC BY 4.0Reference data
CHEBI:73873+sodium(1+)CHEBI:73873+sodium(1+)
Transported by MFSD2A
Reaction pageDirection not assertedBalanced
Rhea RHEA:43860CC BY 4.0Reference data
1 paper
5 names
Resolves to: MFSD2A
1-hexadecanoyl-sn-glycero-3-phosphocholine+sodium(1+)1-hexadecanoyl-sn-glycero-3-phosphocholine+sodium(1+)
Transported by MFSD2A
Reaction pageDirection not assertedBalanced
Rhea RHEA:43864CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphoethanolamine+sodium(1+)a 1-acyl-sn-glycero-3-phosphoethanolamine+sodium(1+)
Transported by MFSD2A
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:43868CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphocholine+sodium(1+)a 1-acyl-sn-glycero-3-phosphocholine+sodium(1+)
Transported by MFSD2A
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:44376CC BY 4.0Reference data