hypotrichosis simplex
Findings
No curated finding names hypotrichosis simplex yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Hypotrichosis simplex (HS) or hereditary hypotrichosis simplex (HHS) is characterized by reduced pilosity over the scalp and body (with sparse, thin, and short hair) in the absence of other anomalies.
Definition from the Mondo Disease Ontology (MONDO:0018914), read 2026-09-29. CC BY 4.0.
Features
6 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AlopeciaHPOHP:0001596
- Very frequent (80% to 99% of cases)
- Sparse body hairHPOHP:0002231
- Very frequent (80% to 99% of cases)
- Sparse eyebrowHPOHP:0045075
- Very frequent (80% to 99% of cases)
- Sparse eyelashesHPOHP:0000653
- Very frequent (80% to 99% of cases)
- Sparse scalp hairHPOHP:0002209
- Very frequent (80% to 99% of cases)
- Sparse hairHPOHP:0008070
- Frequent (30% to 79% of cases)
Genes
7 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- APCDD1HGNC:15718
- Supportive · Orphanet · Autosomal dominant · 2021
- HGNC:21307HGNC:21307
- Supportive · Orphanet · Autosomal dominant · 2021
- LIPHHGNC:18483
- Supportive · Orphanet · Autosomal dominant · 2021
- LPAR6HGNC:15520
- Supportive · Orphanet · Autosomal dominant · 2021
- LSSHGNC:6708
- Supportive · Orphanet · Autosomal dominant · 2021
- RPL21HGNC:10313
Where it sits
- A kind of