Proteins/UNIPROT:Q8N126

CADM3

ProteinUNIPROT:Q8N126

Involved in cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity)..

Function from UniProtKB (Q8N126), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Charcot-Marie-Tooth disease, axonal, type 2FF has a germline basis in CADM3DiseaseGenCC HGNC:17601|MONDO:0030433Inferred only

Statements

17 statements

17 statements · 3 reference databases · Subject: CADM3 · Sources: Hetionet, Reactome, WikiPathways

Order

ENHO covaries with CADM3ProteinHetionet hetionet:covaries:375704-57863Inferred only
GPR173 covaries with CADM3ProteinHetionet hetionet:covaries:54328-57863Inferred only
HOXA5 covaries with CADM3ProteinHetionet hetionet:covaries:3202-57863Inferred only
IQSEC2 covaries with CADM3ProteinHetionet hetionet:covaries:23096-57863Inferred only
NALF2 covaries with CADM3ProteinHetionet hetionet:covaries:27112-57863Inferred only
SNORC covaries with CADM3ProteinHetionet hetionet:covaries:389084-57863Inferred only
SPRED3 covaries with CADM3ProteinHetionet hetionet:covaries:399473-57863Inferred only
SUV39H1 covaries with CADM3ProteinHetionet hetionet:covaries:57863-6839Inferred only
TIGD2 covaries with CADM3ProteinHetionet hetionet:covaries:166815-57863Inferred only
ZNF354B covaries with CADM3ProteinHetionet hetionet:covaries:117608-57863Inferred only
CREB1 interacts with CADM3ProteinHetionet hetionet:interacts:1385-57863Inferred only
CADM3 participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only

Show the remaining 5

CADM3 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
CADM3 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
CADM3 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
CADM3 participates in Nectin/Necl trans heterodimerizationPathwayReactome R-HSA-420597Inferred only
CADM3 participates in Splicing factor NOVA regulated synaptic proteinsPathwayWikiPathways WP4148Inferred only

Other names

10 names

Resolves to: CADM3

Also called: Brain immunoglobulin receptorIGSF4BImmunoglobulin superfamily member 4BNECL-1NECL1Nectin-like protein 1Synaptic cell adhesion molecule 3SYNCAM3TSLC1-like protein 1TSLL1

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