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Proteins/UNIPROT:Q9UJ83
Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids. Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity)..
Function from UniProtKB (Q9UJ83), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
15 statements
15 statements · 5 reference databases · Subject: HACL1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt
7 reactions
MAM03363x2,6,10,14-tetramethylpentadecanal+MAM01836x
Catalysed by HACL1
Reaction pageReversibleBalancedEC 1.2.1.3peroxisome
Human-GEM MAR03385CC BY 4.0Reference data
MAM00655xMAM01836x+2,6,10,14-tetramethylpentadecanal
Catalysed by HACL1
Reaction pageLeft to rightBalancedEC 4.1.-.-peroxisome
Human-GEM MAR03486CC BY 4.0Reference data
CHEBI:57334
6 names
Resolves to: HACL1
Catalysed by HACL1
Reaction pageLeft to rightBalanced
Rhea RHEA:25355CC BY 4.0Reference data
CHEBI:58783CHEBI:49188+CHEBI:57376
Catalysed by HACL1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:25375CC BY 4.0Reference data
CHEBI:58784CHEBI:49190+CHEBI:57376
Catalysed by HACL1
Reaction pageLeft to rightBalanced
Rhea RHEA:25379CC BY 4.0Reference data
2-hydroxyoctadecanoyl-CoACHEBI:138631+CHEBI:57376
Reaction pageLeft to rightBalanced
Rhea RHEA:55196CC BY 4.0Reference data
CHEBI:170012CHEBI:17176+CHEBI:57376
Catalysed by HACL1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67444CC BY 4.0Reference data