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Proteins/UNIPROT:P62495

ETF1

Protein·UNIPROT:P62495

Open in the graph

Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons. The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA. Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes..

Function from UniProtKB (P62495), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

32 statements

32 statements · 4 reference databases · Subject: ETF1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CSNK1A1 interacts with ETF1ProteinHetionet hetionet:interacts:1452-2107Inferred only
EGR1 interacts with ETF1ProteinHetionet hetionet:interacts:1958-2107Inferred only
ETF1 interacts with GSPT1ProteinHetionet hetionet:interacts:2107-2935Inferred only
ETF1 interacts with GSPT2ProteinHetionet hetionet:interacts:2107-23708Inferred only
ETF1 interacts with IKBKEProteinHetionet hetionet:interacts:2107-9641Inferred only
ETF1 interacts with KEAP1ProteinHetionet hetionet:interacts:2107-9817Inferred only
ETF1 interacts with LIG4ProteinHetionet hetionet:interacts:2107-3981Inferred only
ETF1 interacts with PABPC1ProteinHetionet hetionet:interacts:2107-26986Inferred only
ETF1 interacts with PAN3ProteinHetionet hetionet:interacts:2107-255967Inferred only
ETF1 interacts with PPP2CAProteinHetionet hetionet:interacts:2107-5515Inferred only
ETF1 interacts with TRAF6ProteinHetionet hetionet:interacts:2107-7189Inferred only
ETF1 interacts with TSNProteinHetionet hetionet:interacts:2107-7247Inferred only

Show the remaining 20

ETF1 interacts with UBCProteinHetionet hetionet:interacts:2107-7316Inferred only
ETF1 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
ETF1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
ETF1 participates in Eukaryotic Translation TerminationPathwayReactome R-HSA-72764Inferred only
ETF1 participates in Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activationPathwayReactome R-HSA-163841Inferred only
ETF1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ETF1 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
ETF1 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
ETF1 participates in Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)PathwayReactome R-HSA-975957Inferred only
ETF1 participates in Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)PathwayReactome R-HSA-975956Inferred only
ETF1 participates in Nonsense-Mediated Decay (NMD)PathwayReactome R-HSA-927802Inferred only
ETF1 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ETF1 participates in Protein hydroxylationPathwayReactome R-HSA-9629569Inferred only
ETF1 participates in Regulation of expression of SLITs and ROBOsPathwayReactome R-HSA-9010553Inferred only
ETF1 participates in Signaling by ROBO receptorsPathwayReactome R-HSA-376176Inferred only
ETF1 participates in TranslationPathwayReactome R-HSA-72766Inferred only
ETF1 participates in Translation factorsPathwayWikiPathways WP107Inferred only
ETF1 regulates regulation of translational terminationBiological processgene ontology P62495|GO:0006449Inferred only
GATA3 decreases the expression of ETF1ProteinHetionet hetionet:regulates:2625-2107Inferred only
TNFRSF21 decreases the expression of ETF1ProteinHetionet hetionet:regulates:27242-2107Inferred only

Other names

7 names

Resolves to: ETF1

Also called: Cl1ERF1Eukaryotic release factor 1Protein Cl1RF1SUP45L1TB3-1

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