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Proteins/UNIPROT:Q9UPR5
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion..
Function from UniProtKB (Q9UPR5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
37 statements
37 statements · 5 reference databases · Subject: SLC8A2 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea
2 reactions
Ca(2+)+3sodium(1+)Ca(2+)+3sodium(1+)
Transported by SLC8A3 or SLC8A2 or SLC8A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07630CC BY 4.0Reference data
Ca(2+)+3sodium(1+)Ca(2+)+3sodium(1+)
Transported by SLC8A1
4 names
Resolves to: SLC8A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:69955CC BY 4.0Reference data