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Proteins/UNIPROT:Q9GZX3
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Cooperates with B4GALT4 galactosyltransferase and B3GNT7 N-acetylglucosaminyltransferase to construct and elongate the sulfated disaccharide unit [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Involved in biosynthesis of keratan sulfate in cornea, with an impact on proteoglycan fibril organization and corneal transparency. Involved in sulfation of endothelial mucins such as GLYCAM1..
Function from UniProtKB (Q9GZX3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
22 statements
22 statements · 3 reference databases · Subject: CHST6 · Sources: Hetionet, Reactome, WikiPathways
15 reactions
MAM02231g+3'-phospho-5'-adenylyl sulfateproton+MAM02232g+adenosine 3',5'-bismonophosphate
Catalysed by CHST4 or CHST2 or CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07339CC BY 4.0Reference data
MAM02234g+3'-phospho-5'-adenylyl sulfateproton+MAM02235g+adenosine 3',5'-bismonophosphate
8 names
Resolves to: CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07342CC BY 4.0Reference data
MAM02202g+3'-phospho-5'-adenylyl sulfateproton+MAM02203g+adenosine 3',5'-bismonophosphate
Catalysed by CHST4 or CHST2 or CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07345CC BY 4.0Reference data
MAM02205g+3'-phospho-5'-adenylyl sulfateproton+MAM02206g+adenosine 3',5'-bismonophosphate
Catalysed by CHST4 or CHST2 or CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07348CC BY 4.0Reference data
MAM02208g+3'-phospho-5'-adenylyl sulfateproton+MAM02209g+adenosine 3',5'-bismonophosphate
Catalysed by CHST4 or CHST2 or CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07351CC BY 4.0Reference data
MAM02211g+3'-phospho-5'-adenylyl sulfateproton+MAM02213g+adenosine 3',5'-bismonophosphate
Catalysed by CHST4 or CHST2 or CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07354CC BY 4.0Reference data
MAM02215g+3'-phospho-5'-adenylyl sulfateproton+MAM02216g+adenosine 3',5'-bismonophosphate
Catalysed by CHST4 or CHST2 or CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07357CC BY 4.0Reference data
MAM02218g+3'-phospho-5'-adenylyl sulfateproton+MAM02219g+adenosine 3',5'-bismonophosphate
Catalysed by CHST4 or CHST2 or CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07360CC BY 4.0Reference data
MAM02221g+3'-phospho-5'-adenylyl sulfateproton+MAM02222g+adenosine 3',5'-bismonophosphate
Catalysed by CHST4 or CHST2 or CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07363CC BY 4.0Reference data
MAM02225g+3'-phospho-5'-adenylyl sulfateproton+MAM02226g+adenosine 3',5'-bismonophosphate
Catalysed by CHST4 or CHST2 or CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07366CC BY 4.0Reference data
MAM02228g+3'-phospho-5'-adenylyl sulfateproton+MAM02229g+adenosine 3',5'-bismonophosphate
Catalysed by CHST4 or CHST2 or CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07369CC BY 4.0Reference data
MAM02309g+3'-phospho-5'-adenylyl sulfateproton+MAM02310g+adenosine 3',5'-bismonophosphate
Catalysed by CHST4 or CHST2 or CHST6
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07447CC BY 4.0Reference data