Proteins/UNIPROT:P83110

HTRA3

ProteinUNIPROT:P83110

Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization..

Function from UniProtKB (P83110), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 2 reference databases · Subject: HTRA3 · Sources: gene ontology, Hetionet

Order

HTRA3 covaries with BRF1ProteinHetionet hetionet:covaries:2972-94031Inferred only
CARD11 covaries with HTRA3ProteinHetionet hetionet:covaries:84433-94031Inferred only
HTRA3 covaries with CASS4ProteinHetionet hetionet:covaries:57091-94031Inferred only
COL20A1 covaries with HTRA3ProteinHetionet hetionet:covaries:57642-94031Inferred only
HTRA3 covaries with DOK7ProteinHetionet hetionet:covaries:285489-94031Inferred only
HTRA3 covaries with EPS15L1ProteinHetionet hetionet:covaries:58513-94031Inferred only
HTRA3 covaries with GORASP2ProteinHetionet hetionet:covaries:26003-94031Inferred only
MYO9B covaries with HTRA3ProteinHetionet hetionet:covaries:4650-94031Inferred only
HTRA3 covaries with NARFProteinHetionet hetionet:covaries:26502-94031Inferred only
HTRA3 covaries with NUDT4BProteinHetionet hetionet:covaries:11163-94031Inferred only
QSOX2 covaries with HTRA3ProteinHetionet hetionet:covaries:169714-94031Inferred only
RORB covaries with HTRA3ProteinHetionet hetionet:covaries:6096-94031Inferred only

Show the remaining 7

HTRA3 covaries with SNX33ProteinHetionet hetionet:covaries:257364-94031Inferred only
TAF2 covaries with HTRA3ProteinHetionet hetionet:covaries:6873-94031Inferred only
TIFAB covaries with HTRA3ProteinHetionet hetionet:covaries:497189-94031Inferred only
HTRA3 covaries with TNIP2ProteinHetionet hetionet:covaries:79155-94031Inferred only
HTRA3 covaries with WFDC1ProteinHetionet hetionet:covaries:58189-94031Inferred only
HTRA3 regulates negative regulation of BMP signaling pathwayBiological processgene ontology P83110|GO:0030514Inferred only
HTRA3 regulates negative regulation of transforming growth factor beta receptor signaling pathwayBiological processgene ontology P83110|GO:0030512Inferred only

Other names

3 names

Resolves to: HTRA3

Also called: High-temperature requirement factor A3Pregnancy-related serine proteasePRSP

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