Pathway
Synthesis of 12-eicosatetraenoic acid derivatives
The 12-eicosatetraenoic acids: 12-hydroperoxy-eicosatetraenoate (12-HpETE), 12-hydroxyeicosatetraenoate (12-HETE) and 12-oxo-eicosatetraenoate (12-oxoETE) are formed after the initial step of arachidonate oxidation by the arachidonate 12 and 15 lipoxygenases (ALOX12, ALOX12B and ALOX15 respectively). This part of the pathway is bifurcated at the level of 12S-hydroperoxy-eicosatetraenoate (12S-HpETE), which can either be reduced to 12S-hydro-eicosatetraenoate (12S-HETE) or converted to hepoxilins.
REACT:R-HSA-2142712Reactome
What the reference databases state
Statements
7 statements
7 statements · 1 reference database · Subject: Synthesis of 12-eicosatetraenoic acid derivatives · Sources: Reactome
- ALOX12 participates in Synthesis of 12-eicosatetraenoic acid derivativesProteinReactome R-HSA-2142712Inferred only
- ALOX12B participates in Synthesis of 12-eicosatetraenoic acid derivativesProteinReactome R-HSA-2142712Inferred only
- ALOX15 participates in Synthesis of 12-eicosatetraenoic acid derivativesProteinReactome R-HSA-2142712Inferred only
- ALOXE3 participates in Synthesis of 12-eicosatetraenoic acid derivativesProteinReactome R-HSA-2142712Inferred only
- GPX1 participates in Synthesis of 12-eicosatetraenoic acid derivativesProteinReactome R-HSA-2142712Inferred only
- GPX2 participates in Synthesis of 12-eicosatetraenoic acid derivativesProteinReactome R-HSA-2142712Inferred only
- GPX4 participates in Synthesis of 12-eicosatetraenoic acid derivativesProteinReactome R-HSA-2142712Inferred only