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Proteins/UNIPROT:P78524
[Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane..
[Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form..
[Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable)..
Function from UniProtKB (P78524), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
18 statements
18 statements · 3 reference databases · Subject: DENND2B · Sources: gene ontology, Hetionet, Reactome
4 names
Resolves to: DENND2B