Proteins/UNIPROT:O60336

MAPKBP1

ProteinUNIPROT:O60336

Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. Involved in JNK signaling pathway (By similarity)..

Function from UniProtKB (O60336), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

late-onset nephronophthisis has a germline basis in MAPKBP1DiseaseGenCC HGNC:29536|MONDO:0019742Inferred only
nephronophthisis 1 has a germline basis in MAPKBP1DiseaseGenCC HGNC:29536|MONDO:0009728Inferred only
nephronophthisis 20 has a germline basis in MAPKBP1DiseaseGenCC HGNC:29536|MONDO:0014997Inferred only

Statements

12 statements

12 statements · 2 reference databases · Subject: MAPKBP1 · Sources: gene ontology, Hetionet

Order

ALKBH4 covaries with MAPKBP1ProteinHetionet hetionet:covaries:23005-54784Inferred only
OR51G1 covaries with MAPKBP1ProteinHetionet hetionet:covaries:23005-79324Inferred only
ZNF331 covaries with MAPKBP1ProteinHetionet hetionet:covaries:23005-55422Inferred only
MAPKBP1 interacts with APTXProteinHetionet hetionet:interacts:23005-54840Inferred only
CREB1 interacts with MAPKBP1ProteinHetionet hetionet:interacts:1385-23005Inferred only
MAPK10 interacts with MAPKBP1ProteinHetionet hetionet:interacts:23005-5602Inferred only
MAPK8 interacts with MAPKBP1ProteinHetionet hetionet:interacts:23005-5599Inferred only
MAPK9 interacts with MAPKBP1ProteinHetionet hetionet:interacts:23005-5601Inferred only
MAPKBP1 regulates negative regulation of canonical NF-kappaB signal transductionBiological processgene ontology O60336|GO:0043124Inferred only
MAPKBP1 regulates negative regulation of defense response to bacteriumBiological processgene ontology O60336|GO:1900425Inferred only
MAPKBP1 regulates negative regulation of interleukin-8 productionBiological processgene ontology O60336|GO:0032717Inferred only
MAPKBP1 regulates positive regulation of JNK cascadeBiological processgene ontology O60336|GO:0046330Inferred only

Other names

4 names

Resolves to: MAPKBP1

Also called: JNK-binding protein 1JNKBP-1JNKBP1KIAA0596

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