osteochondritis dissecans
Findings
No curated finding names osteochondritis dissecans yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare bone disease characterized by an acquired idiopathic necrotic lesion of subchondral bone with the formation of a sequestrum, which may detach to form loose bodies in joints. OCD mainly affects the knee, ankle and elbow joints and can lead to pain, functional limitations and secondary osteoarthritis.
Definition from the Mondo Disease Ontology (MONDO:0017178), read 2026-09-29. CC BY 4.0.
Features
18 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of the kneeHPOHP:0002815
- Very frequent (80% to 99% of cases)
- ArthralgiaHPOHP:0002829
- Very frequent (80% to 99% of cases)
- Joint stiffnessHPOHP:0001387
- Very frequent (80% to 99% of cases)
- Joint swellingHPOHP:0001386
- Very frequent (80% to 99% of cases)
- Limitation of joint mobilityHPOHP:0001376
- Very frequent (80% to 99% of cases)
- Abnormal joint morphologyHPOHP:0001367
- Frequent (30% to 79% of cases)
- Abnormal musculoskeletal physiologyHPOHP:0011843
- Frequent (30% to 79% of cases)
- Avascular necrosisHPOHP:0010885
- Frequent (30% to 79% of cases)
- Bone marrow edemaHPOHP:6000917
- Frequent (30% to 79% of cases)
- Decreased hip abductionHPOHP:0003184
- Frequent (30% to 79% of cases)
- Joint hypermobilityHPOHP:0001382
- Frequent (30% to 79% of cases)
- Limited elbow extensionHPOHP:0001377
- Frequent (30% to 79% of cases)
Show the remaining 6
- Limited elbow flexionHPOHP:0006376
- Frequent (30% to 79% of cases)
- OsteopeniaHPOHP:0000938
- Frequent (30% to 79% of cases)
- Premature osteoarthritisHPOHP:0003088
- Frequent (30% to 79% of cases)
- Abnormal tibia morphologyHPOHP:0002992
- Occasional (5% to 29% of cases)
- Gait disturbanceHPOHP:0001288
- Occasional (5% to 29% of cases)
- Quadriceps muscle atrophyHPOHP:0009050
- Occasional (5% to 29% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- ACANHGNC:319
- Definitive · Illumina · Autosomal dominant · 2021
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
- A kind of
Other names
5 names
Resolves to: osteochondritis dissecans
- Also called
- Koenig diseaseKonig diseaseKönig diseaseODosteochondritis dissecans (disease)