Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:O60882

MMP20

Protein·UNIPROT:O60882

Open in the graph

Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site..

Function from UniProtKB (O60882), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

amelogenesis imperfecta hypomaturation type 2A2 has a germline basis in MMP20DiseaseGenCC HGNC:7167|MONDO:0012926Inferred only
amelogenesis imperfecta type 2 has a germline basis in MMP20DiseaseGenCC HGNC:7167|MONDO:0015048Inferred only

Statements

11 statements

11 statements · 5 reference databases · Subject: MMP20 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

Search this listOrder

ACAN interacts with MMP20ProteinHetionet hetionet:interacts:176-9313Inferred only
MMP20 participates in Assembly of collagen fibrils and other multimeric structuresPathwayReactome R-HSA-2022090Inferred only
MMP20 participates in Chronic hyperglycemia impairment of neuron functionPathwayWikiPathways WP5283Inferred only
MMP20 participates in Collagen degradationPathwayReactome R-HSA-1442490Inferred only
MMP20 participates in Collagen formationPathwayReactome R-HSA-1474290Inferred only
MMP20 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
MMP20 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
MMP20 participates in Matrix metalloproteinasesPathwayWikiPathways WP129Inferred only
MMP20 regulates regulation of enamel mineralizationBiological processgene ontology O60882|GO:0070173Inferred only
MMP20 requires the cofactor Ca(2+)CompoundUniProt O60882Inferred only
MMP20 requires the cofactor Zn(2+)CompoundUniProt O60882Inferred only

Other names

3 names

Resolves to: MMP20

Also called: Enamel metalloproteinaseEnamelysinMMP-20

← Every protein Find it in the graph →