RHOF GTPase cycle

This pathway catalogues RHOF (RIF) GTPase activator proteins (GAPs) and RHOF effectors. RHOF GTPase is thought to exist in the active GTP-bound state in the absence of any GEF activity. No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOF. RHOF is only found in vertebrates. RHOF regulates cytoskeletal dynamics and promotes the formation of filopodia and stress fibers. RHOF may be involved in actin remodelling in lymphocyte microvilli. In neurons, RHOF contributes to the formation of dendritic spines.

Summary from Reactome (R-HSA-9035034), read 2026-09-23.