Proteins/UNIPROT:Q5JTV8

TOR1AIP1

ProteinUNIPROT:Q5JTV8

Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina..

Function from UniProtKB (Q5JTV8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

autosomal recessive limb-girdle muscular dystrophy type 2Y has a germline basis in TOR1AIP1DiseaseGenCC HGNC:29456|MONDO:0014900Inferred only
TOR1AIP1-related multisystem disorder has a germline basis in TOR1AIP1DiseaseGenCC HGNC:29456|MONDO:0100591Inferred only
TOR1AIP1-related myopathy has a germline basis in TOR1AIP1DiseaseGenCC HGNC:29456|MONDO:0100582Inferred only

Statements

26 statements

26 statements · 4 reference databases · Subject: TOR1AIP1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

FBN3 covaries with TOR1AIP1ProteinHetionet hetionet:covaries:26092-84467Inferred only
GP5 covaries with TOR1AIP1ProteinHetionet hetionet:covaries:26092-2814Inferred only
IRS4 covaries with TOR1AIP1ProteinHetionet hetionet:covaries:26092-8471Inferred only
NID2 covaries with TOR1AIP1ProteinHetionet hetionet:covaries:22795-26092Inferred only
PPP1R15B covaries with TOR1AIP1ProteinHetionet hetionet:covaries:26092-84919Inferred only
RTBDN covaries with TOR1AIP1ProteinHetionet hetionet:covaries:26092-83546Inferred only
ESR1 interacts with TOR1AIP1ProteinHetionet hetionet:interacts:2099-26092Inferred only
LMNA interacts with TOR1AIP1ProteinHetionet hetionet:interacts:26092-4000Inferred only
LMNB1 interacts with TOR1AIP1ProteinHetionet hetionet:interacts:26092-4001Inferred only
PPP1CA interacts with TOR1AIP1ProteinHetionet hetionet:interacts:26092-5499Inferred only
PPP1CC interacts with TOR1AIP1ProteinHetionet hetionet:interacts:26092-5501Inferred only
TERF2 interacts with TOR1AIP1ProteinHetionet hetionet:interacts:26092-7014Inferred only

Show the remaining 14

TOR1AIP1 interacts with TERF2IPProteinHetionet hetionet:interacts:26092-54386Inferred only
TOR1A interacts with TOR1AIP1ProteinHetionet hetionet:interacts:1861-26092Inferred only
TOR1AIP1 interacts with TOR1BProteinHetionet hetionet:interacts:26092-27348Inferred only
TOR1AIP1 interacts with TOR3AProteinHetionet hetionet:interacts:26092-64222Inferred only
UBC interacts with TOR1AIP1ProteinHetionet hetionet:interacts:26092-7316Inferred only
TOR1AIP1 participates in Influence of laminopathies on Wnt signalingPathwayWikiPathways WP4844Inferred only
TOR1AIP1 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
TOR1AIP1 participates in RHOD GTPase cyclePathwayReactome R-HSA-9013405Inferred only
TOR1AIP1 participates in RHOF GTPase cyclePathwayReactome R-HSA-9035034Inferred only
TOR1AIP1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
TOR1AIP1 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
TOR1AIP1 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
TOR1AIP1 regulates positive regulation of ATP-dependent activityBiological processgene ontology Q5JTV8|GO:0032781Inferred only
KDELR2 increases the expression of TOR1AIP1ProteinHetionet hetionet:regulates:11014-26092Inferred only

Other names

3 names

Resolves to: TOR1AIP1

Also called: Lamin-associated protein 1BLAP1LAP1B

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