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Proteins/UNIPROT:Q14781
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression..
Function from UniProtKB (Q14781), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
50 statements
50 statements · 4 reference databases · Subject: CBX2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 name
Resolves to: CBX2