Se-methylselenocysteine

Three steps

• N-docosanoylglycineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by SHMT1, BAATnucleus, cytosol

• N-hexacosanoylglycineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by SHMT1, BAATnucleus, cytosol

• thromboxane B2Reach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. thromboxane B2(out) + 2 (S)-lactate(in) = thromboxane B2(in) + 2 (S)-lactate(out)

  Catalysed by SCLY, LDHA, LDHB, LDHC and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• thiamine(1+) diphosphateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
  3. 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]

  Catalysed by SCLY, PDHA1, PDHB, PDHA2 and 1 morecytosol, mitochondrial matrix