sphinganine 1-phosphate

Three steps

• hexanedioyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 5 morecytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 5 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 7 morecytosol, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 9 morecytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Production of Hexadecanedioylcarnitine

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. fatty-acid-CoA ligase

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 6 morecytosolOne of 2 routes

• undecanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 11 morecytosolOne of 3 routes

• N-hexadecanoyl-sphinganine-1-phosphocholineReach from here →
  1. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  2. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGPP2, SGPP1, CERS6, CERS5 and 3 more

• N-hexadecanoyl-sphinganine-1-phosphoethanolamineReach from here →
  1. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  2. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-sphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGPP2, SGPP1, CERS6, CERS5 and 3 more

• an N-acylsphinganine-1-phosphoethanolamineReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 7 morecytosol

• (5Z)-tetradecenoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 9 morecytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 8 morecytosol, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. 3-sn-phosphatidate phosphohydrolase
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by PLPP1, PLPP3, PLPP2, CERS1 and 13 morecytosolOne of 4 routes