dGMP

Three steps

• thiamine(1+) diphosphateReach from here →
  1. ATP:dGMP phosphotransferase
  2. dADP to dATP conversion
  3. Antiport of thiamine-diphosphate and dATP

  Catalysed by GUK1, SLC25A19cytosol, mitochondrial matrixOne of 2 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. ATP:dGMP phosphotransferase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by GUK1, PKM, PKLR, PDHA1 and 2 morecytosol, mitochondrial matrix