methylarsonate

Three steps

• glycodeoxycholateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by GSTO1, GSTO2, ABCC4inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GSTO1, GSTO2, GPX1, GPX2 and 1 more

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GSTO1, GSTO2, PTGES, MGST3 and 4 more

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GSTO1, GSTO2, GPX1, GPX4

• thromboxane B2Reach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by GSTO1, GSTO2, GPX5, GPX1 and 8 morecytosol, extracellular spaceOne of 2 routes

• an S-substituted glutathioneReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by GSTO1, GSTO2, GSTT4, GSTA4 and 19 moreOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by GSTO1, GSTO2, GPX1, GSTA1 and 2 more

• taurochenodeoxycholateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by GSTO1, GSTO2, ABCC4inner side of the membrane, outer side of the membraneOne of 3 routes