trans-1,2-dithiane-4,5-diol

Three steps

• trans-4-hydroxy-L-prolineReach from here →
  1. Vitamin K:oxidized-dithiothreitol oxidoreductase
  2. selenocysteine lyase (dithiothreitol)
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by VKORC1, SCLY, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-prolineReach from here →
  1. Vitamin K:oxidized-dithiothreitol oxidoreductase
  2. selenocysteine lyase (dithiothreitol)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by VKORC1, SCLY, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-cysteinylglycineReach from here →
  1. Vitamin K:oxidized-dithiothreitol oxidoreductase
  2. selenocysteine lyase (dithiothreitol)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by VKORC1, SCLY, GGTLC3, GGT1 and 4 morecytosolOne of 2 routes

• Mo-molybdopterinReach from here →
  1. Vitamin K:oxidized-dithiothreitol oxidoreductase
  2. selenocysteine lyase (dithiothreitol)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by VKORC1, SCLY, MOCOScytosol

• (2S)-2-aminobutanoateReach from here →
  1. Vitamin K:oxidized-dithiothreitol oxidoreductase
  2. selenocysteine lyase (dithiothreitol)
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by VKORC1, SCLY, AGXT2cytosol