CHEBI:16566

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

602 compounds within 3 steps: 3 in 1, 120 in 2, 479 in 3

Three steps

1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Arachidonate:CoA ligase (AMP-forming)
3. glycerol-3-phosphate 1-O-acyltransferase (arachidonyl-CoA)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 14 morecytosol
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (DHA)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosol
1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. dodecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 12 morecytosol
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosol
1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. a 1-acyl-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. a 1-acyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
3. nonadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 13 morecytosol
1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
3. (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 7 morecytosol
1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosol
1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
3. octanoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosol, mitochondrial matrix
1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosol
1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. medium-chain acyl-CoA ligase (decanoic acid)
3. decanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 9 morecytosol
1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
3. octanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosol, mitochondrial matrix
1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. tetradecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
a 2,3-diacyl-sn-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. acyl-CoA:sphingosine N-acyltransferase
3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 8 morecytosol, Golgi apparatus
1-dodecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 12 morecytosol
1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 12 morecytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 2-(9Z-octadecenoyl)-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 12 morecytosol
eicosan-1-olReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + 2 NADPH + 2 H(+) = eicosan-1-ol + 2 NADP(+) + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 12 morecytosol
hexadecyl (9Z)-hexadecenoateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. hexadecan-1-ol + (9Z)-hexadecenoyl-CoA = hexadecyl (9Z)-hexadecenoate + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 12 morecytosol
hexadecyl octadecanoateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. hexadecan-1-ol + octadecanoyl-CoA = hexadecyl octadecanoate + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosol, mitochondrial matrix
1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosol, mitochondrial matrix
1-O-alkyl-3-acylglycerolReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. acyl-CoA:sphingosine N-acyltransferase
3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 8 morecytosol, Golgi apparatus
hexadecanedioateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Production of Hexadecanedioylcarnitine
3. hexadecanedioyl-CoA + H2O = hexadecanedioate + CoA + H(+)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 6 morecytosol
(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
3. ELOVL fatty acid elongase (trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol, endoplasmic reticulumOne of 2 routes
3-oxo-(11Z)-octadecenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. (9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 12 morecytosol
3-oxo-(13Z)-eicosenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
3. (11Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 6 morecytosol
1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
O-dodecanoyl-R-carnitineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Carnitine O-Palmitoyltransferase
3. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 5 morecytosolOne of 11 routes
1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (DHA)
3. 1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by CERS1, CERS6, CERS3, CERS5 and 11 morecytosol
(11Z,14Z)-eicosadienoateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
3. (11Z,14Z)-eicosadienoyl-CoA hydrolase
Catalysed by CERS1, CERS6, CERS3, CERS5 and 13 morecytosolOne of 13 routes
(17Z)-hexacosenoateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (ximenic acid)
3. Hexacosenoyl-CoA hydrolase
Catalysed by CERS1, CERS6, CERS3, CERS5 and 12 morecytosolOne of 13 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (DPA)
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase
Catalysed by CERS1, CERS6, CERS3, CERS5 and 12 morecytosolOne of 13 routes
(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (adrenic acid)
3. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
Catalysed by CERS1, CERS6, CERS3, CERS5 and 12 morecytosolOne of 14 routes