cis-aconitate

Three steps

• prostaglandin E2Reach from here →
  1. cis-aconitate + H(+) = itaconate + CO2
  2. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  3. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)

  Catalysed by ACOD1, SUGCT, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. cis-aconitate + H(+) = itaconate + CO2
  2. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  3. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by ACOD1, SUGCT, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphateReach from here →
  1. cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)
  2. phosphoenolpyruvate(in) + citrate(out) = phosphoenolpyruvate(out) + citrate(in)
  3. aldehydo-D-mannose 6-phosphate + phosphoenolpyruvate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate

  Catalysed by SLC25A1, NANSinner side of the membrane, outer side of the membrane