CHEBI:15570

Three steps

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. alanine racemase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

  Catalysed by MOCOS, PTGS1, PTGS2cytosolOne of 2 routes

• taurochenodeoxycholateReach from here →
  1. transport of D-alanine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by SLC3A2, SLC7A10, GSS, SLCO1A2 and 2 moreextracellular space, cytosolOne of 3 routes

• thiamine(1+) diphosphateReach from here →
  1. D-alanine:oxygen oxidoreductase (deaminating)
  2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
  3. 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]

  Catalysed by DAO, PDHA1, PDHB, PDHA2 and 1 moreperoxisome, mitochondrial matrix