Papers/PMID:40077784
Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.
Nutrients2025The record
4 findings drawn from this paper, on 1 compound across 4 endpoints, 2 of them null.
What it reported
How to read these marksWhat moved
2 findings
magnesium(2+) — decreases mean power output
PreliminaryGrade D, Preliminary. Non-human or in vitro only.Finding“Compared with the placebo, the mean power output was lower ( p = 0.03) after magnesium supplementation in 11/13 participants (mean decrease of 24 ± 36 W).”
Quoted verbatim from Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.. - Study
- crossover
- Participants
- 13
- Duration
- 9 days
- Dose
- magnesium chloride 300 mg (ReMag) twice per day for 9 days
- Population
- Healthy regularly exercising adults aged 18-40; primary outcome (sprint exercise performance); 30-second all-out cycle ergometer sprint, complete data available for 13 of 15 participants
Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.2025PMID:40077784Industry funded
magnesium(2+) — decreases maximal oxygen uptake
PreliminaryGrade D, Preliminary. Non-human or in vitro only.Finding“Compared with the placebo, the VO2max was lower ( p = 0.005) after magnesium supplementation in 11/15 participants (mean decrease: 3.1 ± 3.6 mL/kg/min).”
Quoted verbatim from Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.. - Study
- crossover
- Participants
- 15
- Duration
- 9 days
- Dose
- magnesium chloride 300 mg (ReMag) twice per day for 9 days
- Population
- Healthy regularly exercising adults aged 18-40 (8 male, 7 female); primary outcome; incremental cycle ergometer test to volitional fatigue with breath-by-breath indirect calorimetry
Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.2025PMID:40077784Industry funded
What did not
2 findings
magnesium(2+) — no detected effect on peak power output
PreliminaryGrade D, Preliminary. Non-human or in vitro only.FindingNull result“The peak power was unaffected by magnesium (655 ± 150 with the placebo vs. 665 ± 185 W with magnesium; p = 0.70).”
Quoted verbatim from Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.. - Study
- crossover
- Participants
- 13
- Duration
- 9 days
- Dose
- magnesium chloride 300 mg (ReMag) twice per day for 9 days
- Population
- Healthy regularly exercising adults aged 18-40; primary outcome (sprint exercise performance); 30-second all-out cycle ergometer sprint, complete data available for 13 of 15 participants
Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.2025PMID:40077784Industry funded
magnesium(2+) — no detected effect on time-trial completion time
PreliminaryGrade D, Preliminary. Non-human or in vitro only.FindingNull result“The time taken to complete the 10 km time trial was not different ( p = 0.89) between the placebo (1282 ± 126 s) and magnesium (1281 ± 97 s).”
Quoted verbatim from Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.. - Study
- crossover
- Participants
- 15
- Duration
- 9 days
- Dose
- magnesium chloride 300 mg (ReMag) twice per day for 9 days
- Population
- Healthy regularly exercising adults aged 18-40; primary outcome; self-paced simulated 10 km stationary cycle ergometer time trial
Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.2025PMID:40077784Industry funded