Papers/PMID:35619221
Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial.
Journal of pineal research2022The record
3 findings · 1 compound · 3 endpoints · 3 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
3 findings
melatonin — no detected effect on lumbar spine bone mineral density
Evidence strength: limited.FindingNull result“Total fat content, total lean body mass, body weight, total bone mineral content, total bone mineral density (BMD), lumbar spine BMD, and total hip BMD were not significantly different after M compared with P (Table 2).”
Quoted verbatim from Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial.. - Study
- crossover
- Duration
- 3 months
- Dose
- 10 mg melatonin 1 h before bedtime for 12 weeks
- Population
- Seventeen men with type 2 diabetes on stable antidiabetic, antihypertensive and lipid-lowering therapy; double-blind placebo-controlled crossover; whole-body DEXA at end of each 12-week period; secondary endpoint
Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial.2022PMID:3561922110.1111/jpi.12809Permalink
melatonin — no detected effect on pittsburgh Sleep Quality Index global score
Evidence strength: very limited.FindingNull result“There were no significant effects of melatonin on daytime sleepiness or sleep quality measured with ESS (p =.84) or PSQI (p =.11), respectively, but a small shift towards eveningness type was seen after melatonin treatment compared with placebo measured with MEQ (difference −2.3 [−3.7 to −0.9], p =.0036) (Table 4).”
Quoted verbatim from Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial.. - Study
- crossover
- Duration
- 3 months
- Dose
- 10 mg melatonin 1 h before bedtime for 12 weeks
- Population
- Seventeen men with type 2 diabetes on stable antidiabetic therapy; double-blind placebo-controlled crossover, measured on the study day at the end of each 12-week period; secondary endpoint
Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial.2022PMID:3561922110.1111/jpi.12809Permalink
melatonin — no detected effect on lean body mass
Evidence strength: very limited.FindingNull result“Total fat content, total lean body mass, body weight, total bone mineral content, total bone mineral density (BMD), lumbar spine BMD, and total hip BMD were not significantly different after M compared with P (Table 2).”
Quoted verbatim from Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial.. - Study
- crossover
- Duration
- 3 months
- Dose
- 10 mg melatonin 1 h before bedtime for 12 weeks
- Population
- Seventeen men with type 2 diabetes on stable antidiabetic, antihypertensive and lipid-lowering therapy; double-blind placebo-controlled crossover; whole-body DEXA at end of each 12-week period; secondary endpoint
Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial.2022PMID:3561922110.1111/jpi.12809Permalink