Papers/PMID:25389959
Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.
The journal of nutrition, health & aging2014The record
4 findings · 1 compound · 4 endpoints · 3 null
What it reported
How to read these marksWhat moved
1 finding
L-glutamine — increases plasma citrulline concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“In plasma (Table 5), both citrulline and proline levels were significantly higher in glutamine-supplemented rats than in controls.”
Quoted verbatim from Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.. - Study
- animal · not in humans
- Dose
- glutamine in drinking water 7 consecutive days a month for 10 months, 20% of dietary protein (about 0.8 g/rat/day)
- Population
- Very old (27-month) female Wistar rats given intermittent oral glutamine for 10 months versus water-only controls
Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.2014PMID:25389959Permalink
What did not
3 findings
L-glutamine — no detected effect on serum creatinine concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Plasma creatinine and urea were similar in very old rats supplemented or not with glutamine (Table 3).”
Quoted verbatim from Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.. - Study
- animal · not in humans
- Dose
- glutamine in drinking water 7 consecutive days a month for 10 months, 20% of dietary protein (about 0.8 g/rat/day)
- Population
- Very old (27-month) female Wistar rats given intermittent oral glutamine for 10 months versus water-only controls
Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.2014PMID:25389959Permalink
L-glutamine — no detected effect on alanine aminotransferase
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.FindingNull result“Likewise ALT and AST were not modified by glutamine supplementation (Table 3).”
Quoted verbatim from Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.. - Study
- animal · not in humans
- Dose
- glutamine in drinking water 7 consecutive days a month for 10 months, 20% of dietary protein (about 0.8 g/rat/day)
- Population
- Very old (27-month) female Wistar rats given intermittent oral glutamine for 10 months versus water-only controls
Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.2014PMID:25389959Permalink
L-glutamine — no detected effect on aspartate aminotransferase
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.FindingNull result“Likewise ALT and AST were not modified by glutamine supplementation (Table 3).”
Quoted verbatim from Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.. - Study
- animal · not in humans
- Dose
- glutamine in drinking water 7 consecutive days a month for 10 months, 20% of dietary protein (about 0.8 g/rat/day)
- Population
- Very old (27-month) female Wistar rats given intermittent oral glutamine for 10 months versus water-only controls
Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.2014PMID:25389959Permalink