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Proteins/UNIPROT:Q9NS56
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation..
Function from UniProtKB (Q9NS56), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
37 statements
37 statements · 4 reference databases · Subject: TOPORS · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 reaction
9 names
Resolves to: TOPORS
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol
Human-GEM MAR09491CC BY 4.0Reference data