Proteins/UNIPROT:Q5SXM2

SNAPC4

ProteinUNIPROT:Q5SXM2

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box..

Function from UniProtKB (Q5SXM2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

neurodevelopmental disorder with motor regression, progressive spastic paraplegia, and oromotor dysfunction has a germline basis in SNAPC4DiseaseGenCC HGNC:11137|MONDO:0957791Inferred only

Statements

48 statements

48 statements · 2 reference databases · Subject: SNAPC4 · Sources: Hetionet, Reactome

Order

ACAD10 covaries with SNAPC4ProteinHetionet hetionet:covaries:6621-80724Inferred only
SNAPC4 covaries with AMER2ProteinHetionet hetionet:covaries:219287-6621Inferred only
DNAAF5 covaries with SNAPC4ProteinHetionet hetionet:covaries:54919-6621Inferred only
SNAPC4 covaries with FBXL18ProteinHetionet hetionet:covaries:6621-80028Inferred only
MAST4 covaries with SNAPC4ProteinHetionet hetionet:covaries:375449-6621Inferred only
SNAPC4 covaries with PPP1R26ProteinHetionet hetionet:covaries:6621-9858Inferred only
SNAPC4 covaries with VRK3ProteinHetionet hetionet:covaries:51231-6621Inferred only
WWC3 covaries with SNAPC4ProteinHetionet hetionet:covaries:55841-6621Inferred only
SNAPC4 interacts with BRF2ProteinHetionet hetionet:interacts:55290-6621Inferred only
MAPK6 interacts with SNAPC4ProteinHetionet hetionet:interacts:5597-6621Inferred only
SNAPC1 interacts with SNAPC4ProteinHetionet hetionet:interacts:6617-6621Inferred only
SNAPC2 interacts with SNAPC4ProteinHetionet hetionet:interacts:6618-6621Inferred only

Show the remaining 36

SNAPC4 interacts with SNAPC5ProteinHetionet hetionet:interacts:10302-6621Inferred only
SNAPC4 interacts with TBPProteinHetionet hetionet:interacts:6621-6908Inferred only
SNAPC4 interacts with UBCProteinHetionet hetionet:interacts:6621-7316Inferred only
SNAPC4 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
SNAPC4 participates in RNA polymerase II transcribes snRNA genesPathwayReactome R-HSA-6807505Inferred only
SNAPC4 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
SNAPC4 participates in RNA Polymerase III Abortive And Retractive InitiationPathwayReactome R-HSA-749476Inferred only
SNAPC4 participates in RNA Polymerase III TranscriptionPathwayReactome R-HSA-74158Inferred only
SNAPC4 participates in RNA Polymerase III Transcription InitiationPathwayReactome R-HSA-76046Inferred only
SNAPC4 participates in RNA Polymerase III Transcription Initiation From Type 3 PromoterPathwayReactome R-HSA-76071Inferred only
SNAPC4 increases the expression of AGR2ProteinHetionet hetionet:regulates:6621-10551Inferred only
SNAPC4 decreases the expression of CAMSAP2ProteinHetionet hetionet:regulates:6621-23271Inferred only
SNAPC4 increases the expression of CCND3ProteinHetionet hetionet:regulates:6621-896Inferred only
SNAPC4 increases the expression of CRIP1ProteinHetionet hetionet:regulates:6621-1396Inferred only
SNAPC4 increases the expression of CRYZProteinHetionet hetionet:regulates:6621-1429Inferred only
SNAPC4 decreases the expression of CSKProteinHetionet hetionet:regulates:6621-1445Inferred only
SNAPC4 decreases the expression of CSNK1EProteinHetionet hetionet:regulates:6621-1454Inferred only
SNAPC4 increases the expression of EAPPProteinHetionet hetionet:regulates:6621-55837Inferred only
SNAPC4 increases the expression of JADE2ProteinHetionet hetionet:regulates:6621-23338Inferred only
SNAPC4 increases the expression of MCOLN1ProteinHetionet hetionet:regulates:6621-57192Inferred only
SNAPC4 increases the expression of MINDY1ProteinHetionet hetionet:regulates:6621-55793Inferred only
SNAPC4 decreases the expression of OXSR1ProteinHetionet hetionet:regulates:6621-9943Inferred only
SNAPC4 increases the expression of PLAC8ProteinHetionet hetionet:regulates:6621-51316Inferred only
SNAPC4 increases the expression of PLS1ProteinHetionet hetionet:regulates:6621-5357Inferred only
SNAPC4 decreases the expression of PPP2R5EProteinHetionet hetionet:regulates:6621-5529Inferred only
SNAPC4 decreases the expression of RND3ProteinHetionet hetionet:regulates:6621-390Inferred only
SNAPC4 increases the expression of RRP8ProteinHetionet hetionet:regulates:6621-23378Inferred only
SNAPC4 increases the expression of SACM1LProteinHetionet hetionet:regulates:6621-22908Inferred only
SNAPC4 increases the expression of SELLProteinHetionet hetionet:regulates:6621-6402Inferred only
SNAPC4 decreases the expression of SGK1ProteinHetionet hetionet:regulates:6621-6446Inferred only
SNAPC4 decreases the expression of SPON2ProteinHetionet hetionet:regulates:6621-10417Inferred only
SNAPC4 decreases the expression of TRIB3ProteinHetionet hetionet:regulates:6621-57761Inferred only
SNAPC4 increases the expression of TSPAN8ProteinHetionet hetionet:regulates:6621-7103Inferred only
SNAPC4 decreases the expression of VEGFAProteinHetionet hetionet:regulates:6621-7422Inferred only
SNAPC4 decreases the expression of ZNF140ProteinHetionet hetionet:regulates:6621-7699Inferred only
SNAPC4 decreases the expression of ZNF395ProteinHetionet hetionet:regulates:6621-55893Inferred only

Other names

7 names

Resolves to: SNAPC4

Also called: Proximal sequence element-binding transcription factor subunit alphaPSE-binding factor subunit alphaPTF subunit alphaSNAP190SNAPc 190 kDa subunitSNAPc subunit 4snRNA-activating protein complex 190 kDa subunit

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